Genome-Wide Investigation of DNA Methylation Marks Associated with FV Leiden Mutation

Dylan Aïssi; Jessica Dennis; Martin Ladouceur; Vinh Truong; Nora Zwingerman; Ares Rocanin-Arjo; Marine Germain; Tara A. Paton; Pierre-Emmanuel Morange; France Gagnon; David-Alexandre Trégouët

doi:10.1371/journal.pone.0108087

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Open Access

Peer-reviewed

Research Article

Genome-Wide Investigation of DNA Methylation Marks Associated with FV Leiden Mutation

Dylan Aïssi,

Affiliations Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France, INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France, ICAN Institute for Cardiometabolism and Nutrition, Paris, France
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Jessica Dennis,

Affiliation Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
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Martin Ladouceur,

Affiliations Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada, Centre de Recherches du CHUM, Montréal, Canada
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Vinh Truong,

Affiliation Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
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Nora Zwingerman,

Affiliation Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
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Ares Rocanin-Arjo,

Affiliations Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France, INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France, ICAN Institute for Cardiometabolism and Nutrition, Paris, France
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Marine Germain,

Affiliations Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France, INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France, ICAN Institute for Cardiometabolism and Nutrition, Paris, France
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Tara A. Paton,

Affiliation The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
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Pierre-Emmanuel Morange,

Affiliations Aix-Marseille University, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, Marseille, France, INSERM, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, Marseille, France, Laboratory of Haematology, La Timone Hospital, Marseille, France
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France Gagnon,

Affiliation Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
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David-Alexandre Trégouët

* E-mail: david.tregouet@upmc.fr

Affiliations Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France, INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France, ICAN Institute for Cardiometabolism and Nutrition, Paris, France
⨯

Genome-Wide Investigation of DNA Methylation Marks Associated with FV Leiden Mutation

Dylan Aïssi,
Jessica Dennis,
Martin Ladouceur,
Vinh Truong,
Nora Zwingerman,
Ares Rocanin-Arjo,
Marine Germain,
Tara A. Paton,
Pierre-Emmanuel Morange,
France Gagnon

Published: September 29, 2014
https://doi.org/10.1371/journal.pone.0108087

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DNA methylation
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Single nucleotide polymorphisms
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Methylation
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Biomarkers
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Genetic loci
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Mutation
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Medical risk factors
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