Pyruvate Induces Transient Tumor Hypoxia by Enhancing Mitochondrial Oxygen Consumption and Potentiates the Anti-Tumor Effect of a Hypoxia-Activated Prodrug TH-302

Yoichi Takakusagi; Shingo Matsumoto; Keita Saito; Masayuki Matsuo; Shun Kishimoto; Jonathan W. Wojtkowiak; William DeGraff; Aparna H. Kesarwala; Rajani Choudhuri; Nallathamby Devasahayam; Sankaran Subramanian; Jeeva P. Munasinghe; Robert J. Gillies; James B. Mitchell; Charles P. Hart; Murali C. Krishna

doi:10.1371/journal.pone.0107995

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Peer-reviewed

Research Article

Pyruvate Induces Transient Tumor Hypoxia by Enhancing Mitochondrial Oxygen Consumption and Potentiates the Anti-Tumor Effect of a Hypoxia-Activated Prodrug TH-302

Yoichi Takakusagi,

Affiliation Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Shingo Matsumoto,

Affiliation Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Keita Saito,

Affiliation Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Masayuki Matsuo,

Affiliation Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Shun Kishimoto,

Affiliation Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Jonathan W. Wojtkowiak,

Affiliation H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
William DeGraff,

Affiliation Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Aparna H. Kesarwala,

Affiliation Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Rajani Choudhuri,

Affiliation Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Nallathamby Devasahayam,

Affiliation Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Sankaran Subramanian,

Affiliation Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Jeeva P. Munasinghe,

Affiliation National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, United States of America
⨯
Robert J. Gillies,

Affiliation H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
James B. Mitchell,

Affiliation Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Charles P. Hart,

Affiliation Threshold Pharmaceuticals, South San Francisco, California, United States of America
⨯
[ ... ],
Murali C. Krishna

* E-mail: murali@helix.nih.gov

Affiliation Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
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Pyruvate Induces Transient Tumor Hypoxia by Enhancing Mitochondrial Oxygen Consumption and Potentiates the Anti-Tumor Effect of a Hypoxia-Activated Prodrug TH-302

Yoichi Takakusagi,
Shingo Matsumoto,
Keita Saito,
Masayuki Matsuo,
Shun Kishimoto,
Jonathan W. Wojtkowiak,
William DeGraff,
Aparna H. Kesarwala,
Rajani Choudhuri,
Nallathamby Devasahayam

Published: September 25, 2014
https://doi.org/10.1371/journal.pone.0107995

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Cancers and neoplasms
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Pyruvate
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Oxygen consumption
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