Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor

• Can Li ,

  Contributed equally to this work with: Can Li, Chuangen Li

  Affiliation Department of Microbiology, The University of Hong Kong, Hong Kong, China

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• Chuangen Li ,

  Contributed equally to this work with: Can Li, Chuangen Li

  Affiliation Department of Microbiology, The University of Hong Kong, Hong Kong, China

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• Anna J. X. Zhang ,

  * E-mail: kyyuen@hkucc.hku.hk (K-YY); zhangajx@hku.hk (AJXZ)

  Affiliations Department of Microbiology, The University of Hong Kong, Hong Kong, China, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China, Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China

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• Kelvin K. W. To,

  Affiliations Department of Microbiology, The University of Hong Kong, Hong Kong, China, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China, Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China

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• Andrew C. Y. Lee,

  Affiliation Department of Microbiology, The University of Hong Kong, Hong Kong, China

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• Houshun Zhu,

  Affiliation Department of Medicine, The University of Hong Kong, Hong Kong, China

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• Hazel W. L. Wu,

  Affiliations Department of Microbiology, The University of Hong Kong, Hong Kong, China, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China

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• Jasper F. W. Chan,

  Affiliations Department of Microbiology, The University of Hong Kong, Hong Kong, China, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China, Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China

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• Honglin Chen,

  Affiliations Department of Microbiology, The University of Hong Kong, Hong Kong, China, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China, Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China, Zhejiang University, Hangzhou, China

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• Ivan F. N. Hung,

  Affiliations Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China, Department of Medicine, The University of Hong Kong, Hong Kong, China

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• Lanjuan Li,

  Affiliations State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China, Zhejiang University, Hangzhou, China

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• Kwok-Yung Yuen

  * E-mail: kyyuen@hkucc.hku.hk (K-YY); zhangajx@hku.hk (AJXZ)

  Affiliations Department of Microbiology, The University of Hong Kong, Hong Kong, China, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China, Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China, Zhejiang University, Hangzhou, China

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