Combining MK626, a Novel DPP-4 Inhibitor, and Low-Dose Monoclonal CD3 Antibody for Stable Remission of New-Onset Diabetes in Mice

Lei Ding; Conny A. Gysemans; Geert Stangé; Yves Heremans; Yixing Yuchi; Tatiana Takiishi; Hannelie Korf; Marie Chintinne; Richard D. Carr; Harry Heimberg; Daniel Pipeleers; Chantal Mathieu

doi:10.1371/journal.pone.0107935

Loading metrics

Open Access

Peer-reviewed

Research Article

Combining MK626, a Novel DPP-4 Inhibitor, and Low-Dose Monoclonal CD3 Antibody for Stable Remission of New-Onset Diabetes in Mice

Lei Ding ,

¶LD and CAG are shared first authors on this work.

Affiliation Laboratory of Clinical and Experimental Endocrinology, Campus Gasthuisberg O&N1, Faculty of Medicine, Katholieke Universiteit Leuven (KU LEUVEN), Leuven, Belgium
⨯
Conny A. Gysemans ,

* E-mail: Conny.Gysemans@med.kuleuven.be (CAG); chantal.mathieu@med.kuleuven.be (CM)

¶LD and CAG are shared first authors on this work.

Affiliation Laboratory of Clinical and Experimental Endocrinology, Campus Gasthuisberg O&N1, Faculty of Medicine, Katholieke Universiteit Leuven (KU LEUVEN), Leuven, Belgium
⨯
Geert Stangé,

Affiliation Laboratory of Diabetes Pathology and Therapy, Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Yves Heremans,

Affiliation Laboratory of Beta Cell Neogenesis (BENE), Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Yixing Yuchi,

Affiliation Laboratory of Beta Cell Neogenesis (BENE), Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Tatiana Takiishi,

Affiliation Laboratory of Clinical and Experimental Endocrinology, Campus Gasthuisberg O&N1, Faculty of Medicine, Katholieke Universiteit Leuven (KU LEUVEN), Leuven, Belgium
⨯
Hannelie Korf,

Affiliation Laboratory of Clinical and Experimental Endocrinology, Campus Gasthuisberg O&N1, Faculty of Medicine, Katholieke Universiteit Leuven (KU LEUVEN), Leuven, Belgium
⨯
Marie Chintinne,

Affiliation Laboratory of Diabetes Pathology and Therapy, Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Richard D. Carr,

Affiliation MSD A/S, Ballerup, Denmark
⨯
Harry Heimberg,

Affiliation Laboratory of Beta Cell Neogenesis (BENE), Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Daniel Pipeleers,

Affiliation Laboratory of Diabetes Pathology and Therapy, Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Chantal Mathieu

* E-mail: Conny.Gysemans@med.kuleuven.be (CAG); chantal.mathieu@med.kuleuven.be (CM)

Affiliation Laboratory of Clinical and Experimental Endocrinology, Campus Gasthuisberg O&N1, Faculty of Medicine, Katholieke Universiteit Leuven (KU LEUVEN), Leuven, Belgium
⨯

Combining MK626, a Novel DPP-4 Inhibitor, and Low-Dose Monoclonal CD3 Antibody for Stable Remission of New-Onset Diabetes in Mice

Lei Ding,
Conny A. Gysemans,
Geert Stangé,
Yves Heremans,
Yixing Yuchi,
Tatiana Takiishi,
Hannelie Korf,
Marie Chintinne,
Richard D. Carr,
Harry Heimberg

Published: September 30, 2014
https://doi.org/10.1371/journal.pone.0107935

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Diabetes mellitus
Is the Subject Area "Diabetes mellitus" applicable to this article?

Thanks for your feedback.
Insulin
Is the Subject Area "Insulin" applicable to this article?

Thanks for your feedback.
Regulatory T cells
Is the Subject Area "Regulatory T cells" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Pancreas
Is the Subject Area "Pancreas" applicable to this article?

Thanks for your feedback.
Blood sugar
Is the Subject Area "Blood sugar" applicable to this article?

Thanks for your feedback.
Insulitis
Is the Subject Area "Insulitis" applicable to this article?

Thanks for your feedback.
Spleen
Is the Subject Area "Spleen" applicable to this article?

Thanks for your feedback.