The KDM2B- Let-7b -EZH2 Axis in Myelodysplastic Syndromes as a Target for Combined Epigenetic Therapy

Ekapun Karoopongse; Cecilia Yeung; John Byon; Aravind Ramakrishnan; Zaneta J. Holman; Peter Y. Z. Jiang; Qiang Yu; H. Joachim Deeg; A. Mario Marcondes

doi:10.1371/journal.pone.0107817

Loading metrics

Open Access

Peer-reviewed

Research Article

The KDM2B- Let-7b -EZH2 Axis in Myelodysplastic Syndromes as a Target for Combined Epigenetic Therapy

Ekapun Karoopongse,

Affiliation Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Cecilia Yeung,

Affiliations Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Anatomic Pathology, University of Washington, Seattle, Washington, United States of America
⨯
John Byon,

Affiliation Department of Hematology, University of Washington, Seattle, Washington, United States of America
⨯
Aravind Ramakrishnan,

Affiliations Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America
⨯
Zaneta J. Holman,

Affiliation Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Peter Y. Z. Jiang,

Affiliation Medical Oncology, Providence Regional Cancer Partnership and the Everett Clinic, Everett, Washington, United States of America
⨯
Qiang Yu,

Affiliation Cancer Biology and Pharmacology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore, China
⨯
H. Joachim Deeg,

Affiliations Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America
⨯
A. Mario Marcondes

* E-mail: mmarcond@fhcrc.org

Affiliations Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America
⨯

The KDM2B- Let-7b -EZH2 Axis in Myelodysplastic Syndromes as a Target for Combined Epigenetic Therapy

Ekapun Karoopongse,
Cecilia Yeung,
John Byon,
Aravind Ramakrishnan,
Zaneta J. Holman,
Peter Y. Z. Jiang,
Qiang Yu,
H. Joachim Deeg,
A. Mario Marcondes

Published: September 16, 2014
https://doi.org/10.1371/journal.pone.0107817

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Bone marrow cells
Is the Subject Area "Bone marrow cells" applicable to this article?

Thanks for your feedback.
Histones
Is the Subject Area "Histones" applicable to this article?

Thanks for your feedback.
Cell proliferation
Is the Subject Area "Cell proliferation" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
DNA methylation
Is the Subject Area "DNA methylation" applicable to this article?

Thanks for your feedback.
Synthesis phase
Is the Subject Area "Synthesis phase" applicable to this article?

Thanks for your feedback.
Epigenetics
Is the Subject Area "Epigenetics" applicable to this article?

Thanks for your feedback.
Epigenetic therapy
Is the Subject Area "Epigenetic therapy" applicable to this article?

Thanks for your feedback.