Distinct ETA Receptor Binding Mode of Macitentan As Determined by Site Directed Mutagenesis

Open Access

Peer-reviewed

Research Article

Distinct ET_A Receptor Binding Mode of Macitentan As Determined by Site Directed Mutagenesis

John Gatfield ,

* E-mail: john.gatfield@actelion.com

Affiliation Actelion Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Celia Mueller Grandjean,

Affiliation Actelion Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Daniel Bur,

Affiliation Actelion Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Martin H. Bolli,

Affiliation Actelion Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Oliver Nayler

Affiliation Actelion Pharmaceuticals Ltd., Allschwil, Switzerland
⨯

Receptor binding assays
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Drug interactions
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Calcium signaling
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Cell binding assay
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Crystal structure
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Chemical dissociation
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Tetracyclines
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Pulmonary arteries
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