Cigarette Smoke Extract Induces a Phenotypic Shift in Epithelial Cells; Involvement of HIF1α in Mesenchymal Transition

Irene M. J. Eurlings; Niki L. Reynaert; Twan van den Beucken; Harry R. Gosker; C. C. de Theije; Fien M. Verhamme; Ken R. Bracke; Emiel F. M. Wouters; Mieke A. Dentener

doi:10.1371/journal.pone.0107757

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Peer-reviewed

Research Article

Cigarette Smoke Extract Induces a Phenotypic Shift in Epithelial Cells; Involvement of HIF1α in Mesenchymal Transition

Irene M. J. Eurlings,

Affiliation Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands
⨯
Niki L. Reynaert,

Affiliation Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands
⨯
Twan van den Beucken,

Affiliation Department of Radiation Oncology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands
⨯
Harry R. Gosker,

Affiliation Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands
⨯
C. C. de Theije,

Affiliation Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands
⨯
Fien M. Verhamme,

Affiliation Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
⨯
Ken R. Bracke,

Affiliation Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
⨯
Emiel F. M. Wouters,

Affiliation Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands
⨯
Mieke A. Dentener

* E-mail: mieke.dentener@maastrichtuniversity.nl

Affiliation Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands
⨯

Cigarette Smoke Extract Induces a Phenotypic Shift in Epithelial Cells; Involvement of HIF1α in Mesenchymal Transition

Irene M. J. Eurlings,
Niki L. Reynaert,
Twan van den Beucken,
Harry R. Gosker,
C. C. de Theije,
Fien M. Verhamme,
Ken R. Bracke,
Emiel F. M. Wouters,
Mieke A. Dentener

Published: October 16, 2014
https://doi.org/10.1371/journal.pone.0107757

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