Design and Synthesis of a Cell-Permeable, Drug-Like Small Molecule Inhibitor Targeting the Polo-Box Domain of Polo-Like Kinase 1

Ganipisetti Srinivasrao; Jung-Eun Park; Sungmin Kim; Mija Ahn; Chaejoon Cheong; Ky-Youb Nam; Pethaiah Gunasekaran; Eunha Hwang; Nam-Hyung Kim; Song Yub Shin; Kyung S. Lee; Eunkyung Ryu; Jeong Kyu Bang

doi:10.1371/journal.pone.0107432

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Peer-reviewed

Research Article

Design and Synthesis of a Cell-Permeable, Drug-Like Small Molecule Inhibitor Targeting the Polo-Box Domain of Polo-Like Kinase 1

Ganipisetti Srinivasrao ,

Contributed equally to this work with: Ganipisetti Srinivasrao, Jung-Eun Park, Sungmin Kim

Affiliation Division of Magnetic Resonance, Korea Basic Science Institute, Ochang, Chung-Buk, Republic of Korea
⨯
Jung-Eun Park ,

Contributed equally to this work with: Ganipisetti Srinivasrao, Jung-Eun Park, Sungmin Kim

Affiliation Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Sungmin Kim ,

Contributed equally to this work with: Ganipisetti Srinivasrao, Jung-Eun Park, Sungmin Kim

Affiliation Division of Magnetic Resonance, Korea Basic Science Institute, Ochang, Chung-Buk, Republic of Korea
⨯
Mija Ahn,

Affiliation Division of Magnetic Resonance, Korea Basic Science Institute, Ochang, Chung-Buk, Republic of Korea
⨯
Chaejoon Cheong,

Affiliation Division of Magnetic Resonance, Korea Basic Science Institute, Ochang, Chung-Buk, Republic of Korea
⨯
Ky-Youb Nam,

Affiliation Institute for Innovative Cancer Research and Department of Convergence Medicine, Asan Medical Center, Seoul, Republic of Korea
⨯
Pethaiah Gunasekaran,

Affiliation Molecular Embryology Laboratory, Department of Animal Sciences, Chungbuk National University, Cheongju, Chung-Buk, Republic of Korea
⨯
Eunha Hwang,

Affiliation Division of Magnetic Resonance, Korea Basic Science Institute, Ochang, Chung-Buk, Republic of Korea
⨯
Nam-Hyung Kim,

Affiliation Molecular Embryology Laboratory, Department of Animal Sciences, Chungbuk National University, Cheongju, Chung-Buk, Republic of Korea
⨯
Song Yub Shin,

Affiliation Department of Bio-Materials, Graduate School and Department of Cellular & Molecular Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea
⨯
Kyung S. Lee,

Affiliation Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Eunkyung Ryu ,

* E-mail: bangjk@kbsi.re.kr (JKB); ekryu@kbsi.re.kr (ER)

Affiliation Division of Magnetic Resonance, Korea Basic Science Institute, Ochang, Chung-Buk, Republic of Korea
⨯
Jeong Kyu Bang

* E-mail: bangjk@kbsi.re.kr (JKB); ekryu@kbsi.re.kr (ER)

Affiliation Division of Magnetic Resonance, Korea Basic Science Institute, Ochang, Chung-Buk, Republic of Korea
⨯

Design and Synthesis of a Cell-Permeable, Drug-Like Small Molecule Inhibitor Targeting the Polo-Box Domain of Polo-Like Kinase 1

Ganipisetti Srinivasrao,
Jung-Eun Park,
Sungmin Kim,
Mija Ahn,
Chaejoon Cheong,
Ky-Youb Nam,
Pethaiah Gunasekaran,
Eunha Hwang,
Nam-Hyung Kim,
Song Yub Shin

Published: September 11, 2014
https://doi.org/10.1371/journal.pone.0107432

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