Optimization of Mucosal Responses after Intramuscular Immunization with Integrase Defective Lentiviral Vector

Alessandra Rossi; Zuleika Michelini; Pasqualina Leone; Martina Borghi; Maria Blasi; Roberta Bona; Massimo Spada; Felicia Grasso; Alessio Gugliotta; Mary E. Klotman; Andrea Cara; Donatella Negri

doi:10.1371/journal.pone.0107377

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Open Access

Peer-reviewed

Research Article

Optimization of Mucosal Responses after Intramuscular Immunization with Integrase Defective Lentiviral Vector

Alessandra Rossi,

Affiliation Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy
⨯
Zuleika Michelini,

Affiliation Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanità, Rome, Italy
⨯
Pasqualina Leone,

Affiliation Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanità, Rome, Italy
⨯
Martina Borghi,

Affiliation Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy
⨯
Maria Blasi,

Current address: Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

Affiliation Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy
⨯
Roberta Bona,

Affiliation Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanità, Rome, Italy
⨯
Massimo Spada,

Affiliation Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy
⨯
Felicia Grasso,

Affiliation Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy
⨯
Alessio Gugliotta,

Affiliation Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanità, Rome, Italy
⨯
Mary E. Klotman,

Affiliation Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Andrea Cara ,

* E-mail: donatella.negri@iss.it (DN); andrea.cara@iss.it (AC)

Affiliation Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanità, Rome, Italy
⨯
Donatella Negri

* E-mail: donatella.negri@iss.it (DN); andrea.cara@iss.it (AC)

Affiliation Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy
⨯

Optimization of Mucosal Responses after Intramuscular Immunization with Integrase Defective Lentiviral Vector

Alessandra Rossi,
Zuleika Michelini,
Pasqualina Leone,
Martina Borghi,
Maria Blasi,
Roberta Bona,
Massimo Spada,
Felicia Grasso,
Alessio Gugliotta,
Mary E. Klotman

Published: September 11, 2014
https://doi.org/10.1371/journal.pone.0107377

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