Combining Structural Modeling with Ensemble Machine Learning to Accurately Predict Protein Fold Stability and Binding Affinity Effects upon Mutation

• Niklas Berliner ,

  Contributed equally to this work with: Niklas Berliner, Joan Teyra, Recep Çolak

  Affiliation Terrence Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, Ontario, Canada

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• Joan Teyra ,

  Contributed equally to this work with: Niklas Berliner, Joan Teyra, Recep Çolak

  Affiliation Terrence Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, Ontario, Canada

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• Recep Çolak ,

  Contributed equally to this work with: Niklas Berliner, Joan Teyra, Recep Çolak

  Affiliations Terrence Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, Ontario, Canada, Department of Computer Science, University of Toronto, Toronto, Ontario, Canada

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• Sebastian Garcia Lopez,

  Affiliations Terrence Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, Ontario, Canada, Universidad Nacional de Colombia, Manizales, Colombia

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• Philip M. Kim

  * E-mail: pi@kimlab.org

  Affiliations Terrence Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Department of Computer Science, University of Toronto, Toronto, Ontario, Canada

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