Methotrexate-Related Response on Human Peripheral Blood Mononuclear Cells May Be Modulated by the Ala16Val-SOD2 Gene Polymorphism

Fernanda Barbisan; Jéssica de Rosso Motta; Alexis Trott; Verônica Azzolin; Eduardo Bortoluzzi Dornelles; Matheus Marcon; Thaís Doeler Algarve; Marta Maria Medeiros Frescura Duarte; Clarice Pinheiro Mostardeiro; Taís Cristina Unfer; Karen Lilian Schott; Ivana Beatrice Mânica da Cruz

doi:10.1371/journal.pone.0107299

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Peer-reviewed

Research Article

Methotrexate-Related Response on Human Peripheral Blood Mononuclear Cells May Be Modulated by the Ala16Val-SOD2 Gene Polymorphism

Fernanda Barbisan,

Affiliation Pharmacology Graduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil
⨯
Jéssica de Rosso Motta,

Affiliation Biogenomic Laboratory, Federal University of Santa Maria, Santa Maria, RS, Brazil
⨯
Alexis Trott,

Affiliation Laboratory of Molecular Biology, University of Western Santa Catarina, UNOESC, Chapecó, SC, Brazil
⨯
Verônica Azzolin,

Affiliation Pharmacology Graduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil
⨯
Eduardo Bortoluzzi Dornelles,

Affiliation Biochemical Toxicology Graduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil
⨯
Matheus Marcon,

Affiliation Biogenomic Laboratory, Federal University of Santa Maria, Santa Maria, RS, Brazil
⨯
Thaís Doeler Algarve,

Affiliation Biochemical Toxicology Graduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil
⨯
Marta Maria Medeiros Frescura Duarte,

Affiliation Biogenomic Laboratory, Federal University of Santa Maria, Santa Maria, RS, Brazil
⨯
Clarice Pinheiro Mostardeiro,

Affiliation Biogenomic Laboratory, Federal University of Santa Maria, Santa Maria, RS, Brazil
⨯
Taís Cristina Unfer,

Affiliation Biogenomic Laboratory, Federal University of Santa Maria, Santa Maria, RS, Brazil
⨯
Karen Lilian Schott,

Affiliation Biochemical Toxicology Graduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil
⨯
Ivana Beatrice Mânica da Cruz

* E-mail: ibmcruz@hotmail.com

Affiliations Biogenomic Laboratory, Federal University of Santa Maria, Santa Maria, RS, Brazil, Pharmacology Graduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil, Biochemical Toxicology Graduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil
⨯

Methotrexate-Related Response on Human Peripheral Blood Mononuclear Cells May Be Modulated by the Ala16Val-SOD2 Gene Polymorphism

Fernanda Barbisan,
Jéssica de Rosso Motta,
Alexis Trott,
Verônica Azzolin,
Eduardo Bortoluzzi Dornelles,
Matheus Marcon,
Thaís Doeler Algarve,
Marta Maria Medeiros Frescura Duarte,
Clarice Pinheiro Mostardeiro,
Taís Cristina Unfer

Published: October 20, 2014
https://doi.org/10.1371/journal.pone.0107299

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