Integrative Genomic Analysis Identifies That SERPINA6-rs1998056 Regulated by FOXA/ERα Is Associated with Female Hepatocellular Carcinoma

Na Shen; Jing Gong; Ying Wang; Jing Tian; Jiaming Qian; Li Zou; Wei Chen; Beibei Zhu; Xinghua Lu; Rong Zhong; Anyuan Guo; Li Wang; Xiaoping Miao

doi:10.1371/journal.pone.0107246

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Research Article

Integrative Genomic Analysis Identifies That SERPINA6-rs1998056 Regulated by FOXA/ERα Is Associated with Female Hepatocellular Carcinoma

Na Shen,

Affiliations State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment & Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences; School of Basic Medicine, Peking Union Medical College, Beijing, China
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Jing Gong,

Affiliation State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment & Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Ying Wang,

Affiliation Wuhan Centers for Disease Prevention and Control, Wuhan, China
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Jing Tian,

Affiliation Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences; School of Basic Medicine, Peking Union Medical College, Beijing, China
⨯
Jiaming Qian,

Affiliation Division of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
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Li Zou,

Affiliation State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment & Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Wei Chen,

Affiliation State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment & Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Beibei Zhu,

Affiliation State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment & Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Xinghua Lu,

Affiliation Division of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
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Rong Zhong,

Affiliation State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment & Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Anyuan Guo,

Affiliation Hubei Bioinformatics and Molecular Imaging Key Laboratory, Department of Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
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Li Wang ,

* E-mail: miaoxp@mail.hust.edu.cn (XM); liwang@ibms.pumc.edu.cn (LW)

Affiliation Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences; School of Basic Medicine, Peking Union Medical College, Beijing, China
⨯
Xiaoping Miao

* E-mail: miaoxp@mail.hust.edu.cn (XM); liwang@ibms.pumc.edu.cn (LW)

Affiliation State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment & Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯

Integrative Genomic Analysis Identifies That SERPINA6-rs1998056 Regulated by FOXA/ERα Is Associated with Female Hepatocellular Carcinoma

Na Shen,
Jing Gong,
Ying Wang,
Jing Tian,
Jiaming Qian,
Li Zou,
Wei Chen,
Beibei Zhu,
Xinghua Lu,
Rong Zhong

Published: September 8, 2014
https://doi.org/10.1371/journal.pone.0107246

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