EGFR-Targeted TRAIL and a Smac Mimetic Synergize to Overcome Apoptosis Resistance in KRAS Mutant Colorectal Cancer Cells

Yvonne Möller; Martin Siegemund; Sven Beyes; Ricarda Herr; Daniele Lecis; Domenico Delia; Roland Kontermann; Tilman Brummer; Klaus Pfizenmaier; Monilola A. Olayioye

doi:10.1371/journal.pone.0107165

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Open Access

Peer-reviewed

Research Article

EGFR-Targeted TRAIL and a Smac Mimetic Synergize to Overcome Apoptosis Resistance in KRAS Mutant Colorectal Cancer Cells

Yvonne Möller,

Affiliation Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
⨯
Martin Siegemund,

Affiliation Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
⨯
Sven Beyes,

Affiliation Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
⨯
Ricarda Herr,

Affiliations Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany, Faculty of Biology, Albert-Ludwigs-University of Freiburg, Freiburg, Germany
⨯
Daniele Lecis,

Affiliation Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Domenico Delia,

Affiliation Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Roland Kontermann,

Affiliation Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
⨯
Tilman Brummer,

Affiliations Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany, Centre for Biological Signalling Studies BIOSS, Albert-Ludwigs-University of Freiburg, Freiburg, Germany
⨯
Klaus Pfizenmaier,

Affiliation Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
⨯
Monilola A. Olayioye

* E-mail: monilola.olayioye@izi.uni-stuttgart.de

Affiliation Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
⨯

EGFR-Targeted TRAIL and a Smac Mimetic Synergize to Overcome Apoptosis Resistance in KRAS Mutant Colorectal Cancer Cells

Yvonne Möller,
Martin Siegemund,
Sven Beyes,
Ricarda Herr,
Daniele Lecis,
Domenico Delia,
Roland Kontermann,
Tilman Brummer,
Klaus Pfizenmaier,
Monilola A. Olayioye

Published: September 8, 2014
https://doi.org/10.1371/journal.pone.0107165

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