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Open Access
Peer-reviewed
Research Article
Impact of EGFR Mutation Detection Methods on the Efficacy of Erlotinib in Patients with Advanced EGFR-Wild Type Lung Adenocarcinoma
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Jeng-Sen Tseng ,
Contributed equally to this work with: Jeng-Sen Tseng, Chih-Liang Wang
Affiliations Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan
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Chih-Liang Wang ,
Contributed equally to this work with: Jeng-Sen Tseng, Chih-Liang Wang
Affiliations Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Department of Medicine, Chang Gung University, Taoyuan, Taiwan
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Ming-Shyan Huang,
Affiliations Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
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Chung-Yu Chen,
Affiliation Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin County, Taiwan
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Cheng-Yu Chang,
Affiliation Division of Chest Medicine, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan
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Tsung-Ying Yang,
Affiliations Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
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Chi-Ren Tsai,
Affiliations Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan, Institute of Molecular Biology, National Chung-Hsing University, Taichung, Taiwan
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Kun-Chieh Chen,
Affiliations Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan
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Kuo-Hsuan Hsu,
Affiliations Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan, Division of Critical Care and Respiratory Therapy, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
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Meen-Hsin Tsai,
Affiliations Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Institute of Statistical Science, Academia Sinica, Taipei, Taiwan
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Sung-Liang Yu,
Affiliations Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, Center for Optoelectronic Biomedicine, College of Medicine, National Taiwan University, Taipei, Taiwan, Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan, Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
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Kang-Yi Su,
Affiliations Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan
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Chih-Wei Wu,
Affiliation Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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Cheng-Ta Yang,
Affiliations Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Department of Respiratory Therapy, College of Medicine, Chang Gung University, Taoyuan, Taiwan
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Yuh-Min Chen ,
* E-mail: august@vghtc.gov.tw (GCC); ymchen@vghtpe.gov.tw (YMC)
¶These authors also contributed equally to this work.
Affiliations Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan
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Gee-Chen Chang
* E-mail: august@vghtc.gov.tw (GCC); ymchen@vghtpe.gov.tw (YMC)
¶These authors also contributed equally to this work.
Affiliations Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Comprehensive Cancer Center, Taichung Veterans General Hospital, Taichung, Taiwan
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Impact of EGFR Mutation Detection Methods on the Efficacy of Erlotinib in Patients with Advanced EGFR-Wild Type Lung Adenocarcinoma
- Jeng-Sen Tseng,
- Chih-Liang Wang,
- Ming-Shyan Huang,
- Chung-Yu Chen,
- Cheng-Yu Chang,
- Tsung-Ying Yang,
- Chi-Ren Tsai,
- Kun-Chieh Chen,
- Kuo-Hsuan Hsu,
- Meen-Hsin Tsai
- Published: September 12, 2014
- https://doi.org/10.1371/journal.pone.0107160