Inhaled Lactonase Reduces Pseudomonas aeruginosa Quorum Sensing and Mortality in Rat Pneumonia

Sami Hraiech; Julien Hiblot; John Lafleur; Hubert Lepidi; Laurent Papazian; Jean-Marc Rolain; Didier Raoult; Mikael Elias; Mark W. Silby; Janek Bzdrenga; Fabienne Bregeon; Eric Chabriere

doi:10.1371/journal.pone.0107125

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Peer-reviewed

Research Article

Inhaled Lactonase Reduces Pseudomonas aeruginosa Quorum Sensing and Mortality in Rat Pneumonia

Sami Hraiech ,

Contributed equally to this work with: Sami Hraiech, Julien Hiblot

Affiliations Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS-IRD 6236, IFR48, Aix-Marseille Université, Marseille, France, Réanimation - Détresses Respiratoires et Infections Sévères, APHM, CHU Nord, Marseille, France
⨯
Julien Hiblot ,

Contributed equally to this work with: Sami Hraiech, Julien Hiblot

Affiliation Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS-IRD 6236, IFR48, Aix-Marseille Université, Marseille, France
⨯
John Lafleur,

Affiliations Department of Biology, University of Massachusetts Dartmouth, Dartmouth, Massachusetts, United States of America, Department of Emergency Medicine, Alpert School of Medicine, Providence, Rhode Island, United States of America
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Hubert Lepidi,

Affiliation Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS-IRD 6236, IFR48, Aix-Marseille Université, Marseille, France
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Laurent Papazian,

Affiliations Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS-IRD 6236, IFR48, Aix-Marseille Université, Marseille, France, Réanimation - Détresses Respiratoires et Infections Sévères, APHM, CHU Nord, Marseille, France
⨯
Jean-Marc Rolain,

Affiliation Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS-IRD 6236, IFR48, Aix-Marseille Université, Marseille, France
⨯
Didier Raoult,

Affiliation Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS-IRD 6236, IFR48, Aix-Marseille Université, Marseille, France
⨯
Mikael Elias,

Affiliation Weizmann Institute of Science, Biological Chemistry, Rehovot, Israel
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Mark W. Silby,

Affiliation Department of Biology, University of Massachusetts Dartmouth, Dartmouth, Massachusetts, United States of America
⨯
Janek Bzdrenga,

Affiliation Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS-IRD 6236, IFR48, Aix-Marseille Université, Marseille, France
⨯
Fabienne Bregeon ,

* E-mail: Fabienne.bregeon@ap-hm.fr (FB); Eric.chabriere@univ-amu.fr (EC)

Affiliation Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS-IRD 6236, IFR48, Aix-Marseille Université, Marseille, France
⨯
Eric Chabriere

* E-mail: Fabienne.bregeon@ap-hm.fr (FB); Eric.chabriere@univ-amu.fr (EC)

Affiliation Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS-IRD 6236, IFR48, Aix-Marseille Université, Marseille, France
⨯

Inhaled Lactonase Reduces Pseudomonas aeruginosa Quorum Sensing and Mortality in Rat Pneumonia

Sami Hraiech,
Julien Hiblot,
John Lafleur,
Hubert Lepidi,
Laurent Papazian,
Jean-Marc Rolain,
Didier Raoult,
Mikael Elias,
Mark W. Silby,
Janek Bzdrenga

Published: October 28, 2014
https://doi.org/10.1371/journal.pone.0107125

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