Synthesis and Characterization of Novel 2-Amino-Chromene-Nitriles that Target Bcl-2 in Acute Myeloid Leukemia Cell Lines

• Hosadurga K. Keerthy ,

  Contributed equally to this work with: Hosadurga K. Keerthy, Manoj Garg

  Affiliation Laboratory of Chemical Biology, Department of Chemistry, Bangalore University, Bangalore, India

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• Manoj Garg ,

  Contributed equally to this work with: Hosadurga K. Keerthy, Manoj Garg

  Affiliation Genomic Oncology Programme, Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

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• Chakrabhavi D. Mohan,

  Affiliation Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India

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• Vikas Madan,

  Affiliation Genomic Oncology Programme, Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

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• Deepika Kanojia,

  Affiliation Genomic Oncology Programme, Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

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• Rangappa Shobith,

  Affiliation Interdisciplinary Research Group of Infectious Diseases, Singapore-MIT Alliance for Research & Technology Centre (SMART), Singapore, Singapore

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• Shivananju Nanjundaswamy,

  Affiliation Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India

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• Daniel J. Mason,

  Affiliation Unilever Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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• Andreas Bender,

  Affiliation Unilever Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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• Basappa ,

  * E-mail: salundibasappa@gmail.com (B); rangappaks@gmail.com (KSR)

  Affiliation Laboratory of Chemical Biology, Department of Chemistry, Bangalore University, Bangalore, India

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• Kanchugarakoppal S. Rangappa ,

  * E-mail: salundibasappa@gmail.com (B); rangappaks@gmail.com (KSR)

  Affiliation Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India

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• H. Phillip Koeffler

  Affiliations Genomic Oncology Programme, Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore, Division of Hematology and Oncology, Cedar-Sinai Medical Centre, Los Angeles, California, United States of America

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