Genome-Wide Meta-Analysis of Myopia and Hyperopia Provides Evidence for Replication of 11 Loci

• Claire L. Simpson ,

  ¶CLS, RW and KO are joint first authors on this work.

  Affiliation National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, United States of America

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• Robert Wojciechowski ,

  ¶CLS, RW and KO are joint first authors on this work.

  Affiliations National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, United States of America, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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• Konrad Oexle ,

  ¶CLS, RW and KO are joint first authors on this work.

  Affiliation Institute of Human Genetics, Technische Universität München, Munich, Germany

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• Federico Murgia,

  Affiliation Institute of Population Genetics, National Research Council of Italy, Sassari, Italy

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• Laura Portas,

  Affiliation Institute of Population Genetics, National Research Council of Italy, Sassari, Italy

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• Xiaohui Li,

  Affiliation Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America

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• Virginie J. M. Verhoeven,

  Affiliations Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands

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• Veronique Vitart,

  Affiliation MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, United Kingdom

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• Maria Schache,

  Affiliation Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia

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• S. Mohsen Hosseini,

  Affiliation Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, and DCCT/EDIC Research Group, The Diabetes Control and Complications Trial and Follow-up Study, The Biostatistics Center, The George Washington University, Rockville, Maryland, United States of America

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• Pirro G. Hysi,

  Affiliation Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Hospital, London, United Kingdom

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• Leslie J. Raffel,

  Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Mary Frances Cotch,

  Affiliation Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Emily Chew,

  Affiliation Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Barbara E. K. Klein,

  Affiliation Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

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• Ronald Klein,

  Affiliation Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

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• Tien Yin Wong,

  Affiliations Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia, Singapore Eye Research Institute, National University of Singapore, Singapore, Singapore

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• Cornelia M. van Duijn,

  Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands

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• Paul Mitchell,

  Affiliation Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia

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• Seang Mei Saw,

  Affiliation Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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• Maurizio Fossarello,

  Affiliation Dipartimento di Scienze Chirurgiche, Clinica Oculistica Universita' degli studi di Cagliari, Cagliari, Italy

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• Jie Jin Wang,

  Affiliations Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia, Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia

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• DCCT/EDIC Research Group,

  Affiliation The Diabetes Control and Complications Trial and Follow-up Study, The Biostatistics Center, The George Washington University, Rockville, Maryland, United States of America

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• Ozren Polašek,

  Affiliation Croatian Centre for Global Health, University of Split Medical School, Split, Croatia

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• Harry Campbell,

  Affiliation Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom

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• Igor Rudan,

  Affiliation Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom

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• Ben A. Oostra,

  Affiliation Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, the Netherlands

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• André G. Uitterlinden,

  Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands, Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague, the Netherlands

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• Albert Hofman,

  Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands, Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague, the Netherlands

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• Fernando Rivadeneira,

  Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands, Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague, the Netherlands

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• Najaf Amin,

  Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands

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• Lennart C. Karssen,

  Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands

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• Johannes R. Vingerling,

  Affiliations Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands

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• Angela Döring,

  Affiliation Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany

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• Thomas Bettecken,

  Affiliation Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany

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• Goran Bencic,

  Affiliation Department of Ophthalmology, Hospital “Sestre Milosrdnice”, Zagreb, Croatia

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• Christian Gieger,

  Affiliation Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany

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• H.-Erich Wichmann,

  Affiliation Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany

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• James F. Wilson,

  Affiliation Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom

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• Cristina Venturini,

  Affiliation Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Hospital, London, United Kingdom

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• Brian Fleck,

  Affiliation Princess Alexandra Eye Pavilion, Edinburgh, United Kingdom

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• Phillippa M. Cumberland,

  Affiliation MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, United Kingdom

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• Jugnoo S. Rahi,

  Affiliations MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, United Kingdom, Institute of Ophthalmology, University College London, London, United Kingdom, Ulverscroft Vision Research Group, Institute of Child Health, University College London, London, United Kingdom

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• Chris J. Hammond,

  Affiliation Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Hospital, London, United Kingdom

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• Caroline Hayward,

  Affiliation MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, United Kingdom

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• Alan F. Wright,

  Affiliation MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, United Kingdom

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• Andrew D. Paterson,

  Affiliation Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, and DCCT/EDIC Research Group, The Diabetes Control and Complications Trial and Follow-up Study, The Biostatistics Center, The George Washington University, Rockville, Maryland, United States of America

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• Paul N. Baird,

  Affiliation Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia

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• Caroline C. W. Klaver,

  Affiliations Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands

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• Jerome I. Rotter,

  Affiliation Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America

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• Mario Pirastu,

  Affiliation Institute of Population Genetics, National Research Council of Italy, Sassari, Italy

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• Thomas Meitinger,

  Affiliations Institute of Human Genetics, Technische Universität München, Munich, Germany, Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany

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• Joan E. Bailey-Wilson ,

  * E-mail: jebw@mail.nih.gov

  Affiliation National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, United States of America

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•  [ ... ],
• Dwight Stambolian

  Affiliation Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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