Angelica Sinensis Polysaccharides Stimulated UDP-Sugar Synthase Genes through Promoting Gene Expression of IGF-1 and IGF1R in Chondrocytes: Promoting Anti-Osteoarthritic Activity

Open Access

Peer-reviewed

Research Article

Yinxian Wen,

Affiliation Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China
⨯
Jing Li,

Affiliation Department of pharmacology, Basic Medical School of Wuhan University, Wuhan, China
⨯
Yang Tan,

Affiliation Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China
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Jun Qin,

Affiliation Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China
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Xianfei Xie,

Affiliation Department of pharmacology, Basic Medical School of Wuhan University, Wuhan, China
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Linlong Wang,

Affiliation Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China
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Qibing Mei,

Affiliation Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi’an, China
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Hui Wang,

Affiliations Department of pharmacology, Basic Medical School of Wuhan University, Wuhan, China, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China
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Jacques Magdalou,

Affiliation UMR 7365 CNRS-Université de Lorraine, Faculté de Médecine, Vandœuvre-lès-Nancy, France
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Liaobin Chen

* E-mail: lbchen@whu.edu.cn

Affiliations Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China
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Chondrocytes
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Gene expression
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Cartilage
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Osteoarthritis
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Insulin
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Articular cartilage
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Insulin-like growth factors
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Polysaccharides
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