A CACNA1C Variant Associated with Reduced Voltage-Dependent Inactivation, Increased Ca_V1.2 Channel Window Current, and Arrhythmogenesis

• Jessica A. Hennessey,

  Affiliations Department of Medicine/Cardiology, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America

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• Nicole J. Boczek,

  Affiliation Departments of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America

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• Yong-Hui Jiang,

  Affiliations Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, United States of America

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• Joelle D. Miller,

  Affiliation Department of Pediatrics, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, United States of America

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• William Patrick,

  Affiliation Department of Medicine/Cardiology, Duke University School of Medicine, Durham, North Carolina, United States of America

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• Ryan Pfeiffer,

  Affiliation Masonic Medical Research Laboratory, Utica, New York, United States of America

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• Brittan S. Sutphin,

  Affiliation Departments of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America

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• David J. Tester,

  Affiliation Departments of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America

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• Hector Barajas-Martinez,

  Affiliation Masonic Medical Research Laboratory, Utica, New York, United States of America

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• Michael J. Ackerman,

  Affiliations Departments of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America, Departments of Internal Medicine and Pediatrics & Adolescent Medicine/Divisions of Cardiovascular Diseases and Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota, United States of America

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• Charles Antzelevitch,

  Affiliation Masonic Medical Research Laboratory, Utica, New York, United States of America

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• Ronald Kanter,

  Affiliations Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Pediatrics/Cardiology, Duke University School of Medicine, Durham, North Carolina, United States of America

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• Geoffrey S. Pitt

  * E-mail: geoffrey.pitt@duke.edu

  Affiliations Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina, United States of America

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