Long-Term Corticosterone Exposure Decreases Insulin Sensitivity and Induces Depressive-Like Behaviour in the C57BL/6NCrl Mouse

Eva L. van Donkelaar; Koen R. D. Vaessen; Jodi L. Pawluski; Annerieke S. Sierksma; Arjan Blokland; Ramón Cañete; Harry W. M. Steinbusch

doi:10.1371/journal.pone.0106960

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Peer-reviewed

Research Article

Long-Term Corticosterone Exposure Decreases Insulin Sensitivity and Induces Depressive-Like Behaviour in the C57BL/6NCrl Mouse

Eva L. van Donkelaar ,

* E-mail: eva.vandonkelaar@maastrichtuniversity.nl

Affiliation School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
⨯
Koen R. D. Vaessen,

Affiliations School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands, Central Laboratory Animal Research Facility, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
⨯
Jodi L. Pawluski,

Affiliations School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands, University of Liege, GIGA-Neurosciences, Liège, Belgium,, Department of Biological Sciences, Irvine Hall, Ohio University, Athens, Ohio, United States of America
⨯
Annerieke S. Sierksma,

Affiliations School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands, VIB Center for the Biology of Disease, Leuven, Belgium, Center for Human Genetics, KU Leuven, Leuven, Belgium
⨯
Arjan Blokland,

Affiliation Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
⨯
Ramón Cañete,

Affiliation Unidad de Endocrinología Pediátrica del Hospital Universitario Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
⨯
Harry W. M. Steinbusch

Affiliation School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
⨯

Long-Term Corticosterone Exposure Decreases Insulin Sensitivity and Induces Depressive-Like Behaviour in the C57BL/6NCrl Mouse

Eva L. van Donkelaar,
Koen R. D. Vaessen,
Jodi L. Pawluski,
Annerieke S. Sierksma,
Arjan Blokland,
Ramón Cañete,
Harry W. M. Steinbusch

Published: October 13, 2014
https://doi.org/10.1371/journal.pone.0106960

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Insulin
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Water resources
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Blood plasma
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Animal behavior
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Glucose
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Oral glucose suppression test
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Depression
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