Phosphoproteomics-Mediated Identification of Fer Kinase as a Target of Mutant Shp2 in Noonan and LEOPARD Syndrome

Jeroen Paardekooper Overman; Christian Preisinger; Karin Prummel; Monica Bonetti; Piero Giansanti; Albert Heck; Jeroen den Hertog

doi:10.1371/journal.pone.0106682

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Peer-reviewed

Research Article

Phosphoproteomics-Mediated Identification of Fer Kinase as a Target of Mutant Shp2 in Noonan and LEOPARD Syndrome

Jeroen Paardekooper Overman,

Affiliation Hubrecht Institute-Koninklijke Nederlandse Akademie van Wetenschappen and University Medical Center Utrecht, Utrecht, The Netherlands
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Christian Preisinger,

Affiliations Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Research, Utrecht University, Utrecht, The Netherlands, Netherlands Proteomics Centre, Utrecht, The Netherlands, Proteomics Facility, Interdisciplinary Centre for Clinical Research Aachen, Aachen University, Aachen, Germany
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Karin Prummel,

Affiliation Hubrecht Institute-Koninklijke Nederlandse Akademie van Wetenschappen and University Medical Center Utrecht, Utrecht, The Netherlands
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Monica Bonetti,

Affiliation Hubrecht Institute-Koninklijke Nederlandse Akademie van Wetenschappen and University Medical Center Utrecht, Utrecht, The Netherlands
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Piero Giansanti,

Affiliations Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Research, Utrecht University, Utrecht, The Netherlands, Netherlands Proteomics Centre, Utrecht, The Netherlands
⨯
Albert Heck,

Affiliations Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Research, Utrecht University, Utrecht, The Netherlands, Netherlands Proteomics Centre, Utrecht, The Netherlands, Centre for Biomedical Genetics, Utrecht, The Netherlands
⨯
Jeroen den Hertog

* E-mail: j.denhertog@hubrecht.eu

Affiliations Hubrecht Institute-Koninklijke Nederlandse Akademie van Wetenschappen and University Medical Center Utrecht, Utrecht, The Netherlands, Institute Biology Leiden, Leiden, The Netherlands
⨯

Phosphoproteomics-Mediated Identification of Fer Kinase as a Target of Mutant Shp2 in Noonan and LEOPARD Syndrome

Jeroen Paardekooper Overman,
Christian Preisinger,
Karin Prummel,
Monica Bonetti,
Piero Giansanti,
Albert Heck,
Jeroen den Hertog

Published: September 3, 2014
https://doi.org/10.1371/journal.pone.0106682

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