Extensive Recombination Due to Heteroduplexes Generates Large Amounts of Artificial Gene Fragments during PCR

Open Access

Peer-reviewed

Research Article

Jia Liu,

Affiliation Department of Microbiology, Peking University Health Science Center, Beijing, China
⨯
Hongshuo Song,

Affiliation Department of Medicine, Duke University Medical Center, Durham, North Carolina, United State of America
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Donglai Liu,

Affiliations Department of Medicine, Duke University Medical Center, Durham, North Carolina, United State of America, National Engineering Laboratory for AIDS Vaccine, College of Life Science, Jilin University, Changchun, Jilin, China
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Tao Zuo,

Affiliations Department of Medicine, Duke University Medical Center, Durham, North Carolina, United State of America, National Engineering Laboratory for AIDS Vaccine, College of Life Science, Jilin University, Changchun, Jilin, China
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Fengmin Lu,

Affiliation Department of Microbiology, Peking University Health Science Center, Beijing, China
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Hui Zhuang,

Affiliation Department of Microbiology, Peking University Health Science Center, Beijing, China
⨯
Feng Gao

* E-mail: fgao@duke.edu

Affiliations Department of Medicine, Duke University Medical Center, Durham, North Carolina, United State of America, National Engineering Laboratory for AIDS Vaccine, College of Life Science, Jilin University, Changchun, Jilin, China
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Polymerase chain reaction
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DNA recombination
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Genomics
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Recombination reactions
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Signal amplification
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Next-generation sequencing
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HIV-1
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Nucleotides
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