Platform Comparison for Evaluation of ALK Protein Immunohistochemical Expression, Genomic Copy Number and Hotspot Mutation Status in Neuroblastomas

Benedict Yan; Chik Hong Kuick; Malcolm Lim; Kavita Venkataraman; Chandana Tennakoon; Eva Loh; Derrick Lian; May Ying Leong; Manikandan Lakshmanan; Vinay Tergaonkar; Wing-Kin Sung; Shui Yen Soh; Kenneth T. E. Chang

doi:10.1371/journal.pone.0106575

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Open Access

Peer-reviewed

Research Article

Platform Comparison for Evaluation of ALK Protein Immunohistochemical Expression, Genomic Copy Number and Hotspot Mutation Status in Neuroblastomas

Benedict Yan ,

Contributed equally to this work with: Benedict Yan, Chik Hong Kuick

* E-mail: tranceblues@gmail.com (BY); Kenneth.chang.te@kkh.com.sg (KTEC)

Affiliation Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
⨯
Chik Hong Kuick ,

Contributed equally to this work with: Benedict Yan, Chik Hong Kuick

Affiliation Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
⨯
Malcolm Lim,

Affiliation Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
⨯
Kavita Venkataraman,

Affiliation Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore
⨯
Chandana Tennakoon,

Affiliation Genome Institute of Singapore, Singapore, Singapore
⨯
Eva Loh,

Affiliation Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
⨯
Derrick Lian,

Affiliation Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
⨯
May Ying Leong,

Affiliation Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
⨯
Manikandan Lakshmanan,

Affiliation Mouse Models for Human Cancer Unit, Institute of Molecular and Cell Biology, Singapore, Singapore
⨯
Vinay Tergaonkar,

Affiliation Mouse Models for Human Cancer Unit, Institute of Molecular and Cell Biology, Singapore, Singapore
⨯
Wing-Kin Sung,

Affiliations Genome Institute of Singapore, Singapore, Singapore, School of Computing, National University of Singapore, Singapore, Singapore
⨯
Shui Yen Soh,

Affiliation Haematology/Oncology Service, Department of Paediatric Subspecialties, KK Women's and Children's Hospital, Singapore, Singapore
⨯
Kenneth T. E. Chang

* E-mail: tranceblues@gmail.com (BY); Kenneth.chang.te@kkh.com.sg (KTEC)

Affiliation Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore
⨯

Platform Comparison for Evaluation of ALK Protein Immunohistochemical Expression, Genomic Copy Number and Hotspot Mutation Status in Neuroblastomas

Benedict Yan,
Chik Hong Kuick,
Malcolm Lim,
Kavita Venkataraman,
Chandana Tennakoon,
Eva Loh,
Derrick Lian,
May Ying Leong,
Manikandan Lakshmanan,
Vinay Tergaonkar

Published: September 4, 2014
https://doi.org/10.1371/journal.pone.0106575

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Immunohistochemistry techniques
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Neuroblastoma
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Cancers and neoplasms
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Genomics
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Signal amplification
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Dideoxy DNA sequencing
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Biomarkers
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Protein expression
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