Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome

Susana García-Cerro; Paula Martínez; Verónica Vidal; Andrea Corrales; Jesús Flórez; Rebeca Vidal; Noemí Rueda; María L. Arbonés; Carmen Martínez-Cué

doi:10.1371/journal.pone.0106572

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Peer-reviewed

Research Article

Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome

Susana García-Cerro,

Affiliation Department of Physiology and Pharmacology, Faculty of Medicine, University of Cantabria, Santander, Spain
⨯
Paula Martínez,

Affiliation Department of Physiology and Pharmacology, Faculty of Medicine, University of Cantabria, Santander, Spain
⨯
Verónica Vidal,

Affiliation Department of Physiology and Pharmacology, Faculty of Medicine, University of Cantabria, Santander, Spain
⨯
Andrea Corrales,

Affiliation Department of Physiology and Pharmacology, Faculty of Medicine, University of Cantabria, Santander, Spain
⨯
Jesús Flórez,

Affiliation Department of Physiology and Pharmacology, Faculty of Medicine, University of Cantabria, Santander, Spain
⨯
Rebeca Vidal,

Affiliations Department of Physiology and Pharmacology, Faculty of Medicine, University of Cantabria, Santander, Spain, Institute of Biomedicine and Biotechnology (IBBITEC), (University of Cantabria- Consejo Superior de Investigaciones Científicas (CSIC) and Investigación, Desarrollo e Investigación Cantabria (IDICAN)), Santander, Spain, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
⨯
Noemí Rueda,

Affiliation Department of Physiology and Pharmacology, Faculty of Medicine, University of Cantabria, Santander, Spain
⨯
María L. Arbonés,

Affiliation Barcelona Institute of Molecular Biology, Centro Superior de Investigaciones Científicas (CSIC) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain
⨯
Carmen Martínez-Cué

* E-mail: martinec@unican.es

Affiliation Department of Physiology and Pharmacology, Faculty of Medicine, University of Cantabria, Santander, Spain
⨯

Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome

Susana García-Cerro,
Paula Martínez,
Verónica Vidal,
Andrea Corrales,
Jesús Flórez,
Rebeca Vidal,
Noemí Rueda,
María L. Arbonés,
Carmen Martínez-Cué

Published: September 4, 2014
https://doi.org/10.1371/journal.pone.0106572

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