Pan-Bcl-2 Inhibitor Obatoclax Delays Cell Cycle Progression and Blocks Migration of Colorectal Cancer Cells

Bruno Christian Koehler; Anna-Lena Scherr; Stephan Lorenz; Christin Elssner; Nicole Kautz; Stefan Welte; Dirk Jaeger; Toni Urbanik; Henning Schulze-Bergkamen

doi:10.1371/journal.pone.0106571

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Open Access

Peer-reviewed

Research Article

Pan-Bcl-2 Inhibitor Obatoclax Delays Cell Cycle Progression and Blocks Migration of Colorectal Cancer Cells

Bruno Christian Koehler ,

* E-mail: Bruno.koehler@nct-heidelberg.de

Affiliation National Center for Tumor Diseases, Department of Medical Oncology, Internal Medicine VI, Heidelberg University Hospital, Heidelberg, Germany
⨯
Anna-Lena Scherr,

Affiliation National Center for Tumor Diseases, Department of Medical Oncology, Internal Medicine VI, Heidelberg University Hospital, Heidelberg, Germany
⨯
Stephan Lorenz,

Affiliation National Center for Tumor Diseases, Department of Medical Oncology, Internal Medicine VI, Heidelberg University Hospital, Heidelberg, Germany
⨯
Christin Elssner,

Affiliation National Center for Tumor Diseases, Department of Medical Oncology, Internal Medicine VI, Heidelberg University Hospital, Heidelberg, Germany
⨯
Nicole Kautz,

Affiliation National Center for Tumor Diseases, Department of Medical Oncology, Internal Medicine VI, Heidelberg University Hospital, Heidelberg, Germany
⨯
Stefan Welte,

Affiliation National Center for Tumor Diseases, Department of Medical Oncology, Internal Medicine VI, Heidelberg University Hospital, Heidelberg, Germany
⨯
Dirk Jaeger,

Affiliation National Center for Tumor Diseases, Department of Medical Oncology, Internal Medicine VI, Heidelberg University Hospital, Heidelberg, Germany
⨯
Toni Urbanik,

Affiliation National Center for Tumor Diseases, Department of Medical Oncology, Internal Medicine VI, Heidelberg University Hospital, Heidelberg, Germany
⨯
Henning Schulze-Bergkamen

Affiliation National Center for Tumor Diseases, Department of Medical Oncology, Internal Medicine VI, Heidelberg University Hospital, Heidelberg, Germany
⨯

Pan-Bcl-2 Inhibitor Obatoclax Delays Cell Cycle Progression and Blocks Migration of Colorectal Cancer Cells

Bruno Christian Koehler,
Anna-Lena Scherr,
Stephan Lorenz,
Christin Elssner,
Nicole Kautz,
Stefan Welte,
Dirk Jaeger,
Toni Urbanik,
Henning Schulze-Bergkamen

Published: September 5, 2014
https://doi.org/10.1371/journal.pone.0106571

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