Transforming Growth Factor β and Insulin Signal Changes in Stromal Fibroblasts of Individual Keratoconus Patients

James Foster; Wai-Hong Wu; Sherri-Gae Scott; Mehak Bassi; Divya Mohan; Yassine Daoud; Walter J. Stark; Albert S. Jun; Shukti Chakravarti

doi:10.1371/journal.pone.0106556

Loading metrics

Open Access

Peer-reviewed

Research Article

Transforming Growth Factor β and Insulin Signal Changes in Stromal Fibroblasts of Individual Keratoconus Patients

James Foster ,

Contributed equally to this work with: James Foster, Wai-Hong Wu

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Wai-Hong Wu ,

Contributed equally to this work with: James Foster, Wai-Hong Wu

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Sherri-Gae Scott,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Mehak Bassi,

Affiliation All India Institute of Medical Sciences, New Delhi, India
⨯
Divya Mohan,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Yassine Daoud,

Affiliation Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Walter J. Stark,

Affiliation Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Albert S. Jun,

Affiliation Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Shukti Chakravarti

* E-mail: schakra1@jhmi.edu

Affiliations Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

Transforming Growth Factor β and Insulin Signal Changes in Stromal Fibroblasts of Individual Keratoconus Patients

James Foster,
Wai-Hong Wu,
Sherri-Gae Scott,
Mehak Bassi,
Divya Mohan,
Yassine Daoud,
Walter J. Stark,
Albert S. Jun,
Shukti Chakravarti

Published: September 23, 2014
https://doi.org/10.1371/journal.pone.0106556

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cornea
Is the Subject Area "Cornea" applicable to this article?

Thanks for your feedback.
Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.
Stromal cells
Is the Subject Area "Stromal cells" applicable to this article?

Thanks for your feedback.
Glucose
Is the Subject Area "Glucose" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Insulin
Is the Subject Area "Insulin" applicable to this article?

Thanks for your feedback.
Proteoglycans
Is the Subject Area "Proteoglycans" applicable to this article?

Thanks for your feedback.
SMAD signaling
Is the Subject Area "SMAD signaling" applicable to this article?

Thanks for your feedback.