The Oxidative Stress Product Carboxyethylpyrrole Potentiates TLR2/TLR1 Inflammatory Signaling in Macrophages

Ali M. Saeed; Stephanie Duffort; Dmitry Ivanov; Hua Wang; James M. Laird; Robert G. Salomon; Fernando Cruz-Guilloty; Victor L. Perez

doi:10.1371/journal.pone.0106421

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Peer-reviewed

Research Article

The Oxidative Stress Product Carboxyethylpyrrole Potentiates TLR2/TLR1 Inflammatory Signaling in Macrophages

Ali M. Saeed,

Affiliation Sheila and David Fuente Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Stephanie Duffort,

Affiliation Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Dmitry Ivanov,

Affiliation Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Hua Wang,

Affiliation Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
James M. Laird,

Affiliation Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Robert G. Salomon,

Affiliation Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Fernando Cruz-Guilloty ,

* E-mail: Vperez4@med.miami.edu (VLP); Fcruzguilloty@gmail.com (FC-G)

Current address: Immucor, Inc., Norcross, Georgia, United States of America

Affiliations Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Victor L. Perez

* E-mail: Vperez4@med.miami.edu (VLP); Fcruzguilloty@gmail.com (FC-G)

Affiliations Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯

The Oxidative Stress Product Carboxyethylpyrrole Potentiates TLR2/TLR1 Inflammatory Signaling in Macrophages

Ali M. Saeed,
Stephanie Duffort,
Dmitry Ivanov,
Hua Wang,
James M. Laird,
Robert G. Salomon,
Fernando Cruz-Guilloty,
Victor L. Perez

Published: September 3, 2014
https://doi.org/10.1371/journal.pone.0106421

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