Cardiac Overexpression of Constitutively Active Galpha q Causes Angiotensin II Type1 Receptor Activation, Leading to Progressive Heart Failure and Ventricular Arrhythmias in Transgenic Mice

• Naoko Matsushita,

  Affiliations Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences, Shiwa, Iwate, Japan, Department of Pharmacology, Iwate Medical University School of Medicine, Shiwa, Iwate, Japan

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• Toshihide Kashihara,

  Affiliation Department of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

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• Hisashi Shimojo,

  Affiliation Department of Pathology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

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• Satoshi Suzuki,

  Affiliation Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Fukushima, Japan

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• Tsutomu Nakada,

  Affiliation Department of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

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• Yasuchika Takeishi,

  Affiliation Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Fukushima, Japan

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• Ulrike Mende,

  Affiliation Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital & The Alpert Medical School of Brown University, Providence, Rhode Island, United States of America

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• Eiichi Taira,

  Affiliation Department of Pharmacology, Iwate Medical University School of Medicine, Shiwa, Iwate, Japan

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• Mitsuhiko Yamada,

  Affiliation Department of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

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• Atsushi Sanbe,

  Affiliation Department of Pharmacotherapeutics, Iwate Medical University School of Pharmaceutical Sciences, Shiwa, Iwate, Japan

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• Masamichi Hirose

  * E-mail: mhirose@iwate-med.ac.jp

  Affiliation Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences, Shiwa, Iwate, Japan

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