MALDI Imaging Mass Spectrometry Profiling of N-Glycans in Formalin-Fixed Paraffin Embedded Clinical Tissue Blocks and Tissue Microarrays

Thomas W. Powers; Benjamin A. Neely; Yuan Shao; Huiyuan Tang; Dean A. Troyer; Anand S. Mehta; Brian B. Haab; Richard R. Drake

doi:10.1371/journal.pone.0106255

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Peer-reviewed

Research Article

MALDI Imaging Mass Spectrometry Profiling of N-Glycans in Formalin-Fixed Paraffin Embedded Clinical Tissue Blocks and Tissue Microarrays

Thomas W. Powers,

Affiliation Department of Cell and Molecular Pharmacology and Experimental Therapeutics and MUSC Proteomics Center, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Benjamin A. Neely,

Affiliation Department of Cell and Molecular Pharmacology and Experimental Therapeutics and MUSC Proteomics Center, Medical University of South Carolina, Charleston, South Carolina, United States of America
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Yuan Shao,

Affiliation Hollings Cancer Center Biorepository and Tissue Analysis Resource, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Huiyuan Tang,

Affiliation Laboratory of Cancer Immunodiagnostics, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
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Dean A. Troyer,

Affiliation Departments of Pathology and Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
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Anand S. Mehta,

Affiliation Drexel University College of Medicine, Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology, Doylestown, Pennsylvania, United States of America
⨯
Brian B. Haab,

Affiliation Laboratory of Cancer Immunodiagnostics, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
⨯
Richard R. Drake

* E-mail: draker@musc.edu

Affiliations Department of Cell and Molecular Pharmacology and Experimental Therapeutics and MUSC Proteomics Center, Medical University of South Carolina, Charleston, South Carolina, United States of America, Hollings Cancer Center Biorepository and Tissue Analysis Resource, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯

MALDI Imaging Mass Spectrometry Profiling of N-Glycans in Formalin-Fixed Paraffin Embedded Clinical Tissue Blocks and Tissue Microarrays

Thomas W. Powers,
Benjamin A. Neely,
Yuan Shao,
Huiyuan Tang,
Dean A. Troyer,
Anand S. Mehta,
Brian B. Haab,
Richard R. Drake

Published: September 3, 2014
https://doi.org/10.1371/journal.pone.0106255

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