Exposure to Low-Dose Bisphenol A Impairs Meiosis in the Rat Seminiferous Tubule Culture Model: A Physiotoxicogenomic Approach

Sazan Ali; Gérard Steinmetz; Guillaume Montillet; Marie-Hélène Perrard; Anderson Loundou; Philippe Durand; Marie-Roberte Guichaoua; Odette Prat

doi:10.1371/journal.pone.0106245

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Peer-reviewed

Research Article

Exposure to Low-Dose Bisphenol A Impairs Meiosis in the Rat Seminiferous Tubule Culture Model: A Physiotoxicogenomic Approach

Sazan Ali,

Affiliation Institut Méditerranéen de Biodiversité et d'Ecologie marine et continentale (IMBE), Centre National de la Recherche Scientifique (CNRS) UMR 7263/ Institut de Recherche pour le Développement (IRD) 237, Faculté de Médecine, Aix-Marseille Université (AMU), Marseille, France
⨯
Gérard Steinmetz,

Affiliation Institute of Environmental Biology and Biotechnology (IBEB), Life Science division, French Alternative Energy and Atomic Energy Commission (CEA), Marcoule, Bagnols-sur-Cèze, France
⨯
Guillaume Montillet,

Affiliation Institut de Génomique Fonctionnelle de Lyon (IGFL), Centre National de la Recherche Scientifique (CNRS) UMR 5242/ Institut National de la Recherche Agronomique (INRA), Ecole Normale Supérieure de Lyon (ENS), Lyon, France
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Marie-Hélène Perrard,

Affiliation Institut de Génomique Fonctionnelle de Lyon (IGFL), Centre National de la Recherche Scientifique (CNRS) UMR 5242/ Institut National de la Recherche Agronomique (INRA), Ecole Normale Supérieure de Lyon (ENS), Lyon, France
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Anderson Loundou,

Affiliation Unité d'Aide Méthodologique à la Recherche clinique, Faculté de Médecine, Aix-Marseille Université (AMU), Marseille, France
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Philippe Durand,

Current address: Kallistem SAS, ENS, Lyon, France

Affiliation Institut de Génomique Fonctionnelle de Lyon (IGFL), Centre National de la Recherche Scientifique (CNRS) UMR 5242/ Institut National de la Recherche Agronomique (INRA), Ecole Normale Supérieure de Lyon (ENS), Lyon, France
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Marie-Roberte Guichaoua ,

Contributed equally to this work with: Marie-Roberte Guichaoua, Odette Prat

Affiliation Institut Méditerranéen de Biodiversité et d'Ecologie marine et continentale (IMBE), Centre National de la Recherche Scientifique (CNRS) UMR 7263/ Institut de Recherche pour le Développement (IRD) 237, Faculté de Médecine, Aix-Marseille Université (AMU), Marseille, France
⨯
Odette Prat

Contributed equally to this work with: Marie-Roberte Guichaoua, Odette Prat

* E-mail: odette.prat@cea.fr

Affiliation Institute of Environmental Biology and Biotechnology (IBEB), Life Science division, French Alternative Energy and Atomic Energy Commission (CEA), Marcoule, Bagnols-sur-Cèze, France
⨯

Exposure to Low-Dose Bisphenol A Impairs Meiosis in the Rat Seminiferous Tubule Culture Model: A Physiotoxicogenomic Approach

Sazan Ali,
Gérard Steinmetz,
Guillaume Montillet,
Marie-Hélène Perrard,
Anderson Loundou,
Philippe Durand,
Marie-Roberte Guichaoua,
Odette Prat

Published: September 2, 2014
https://doi.org/10.1371/journal.pone.0106245

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Gene expression
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Pollutants
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Meiotic prophase
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Transcriptome analysis
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Meiosis
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Spermatocytes
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