Overexpression of Mitochondrial Sirtuins Alters Glycolysis and Mitochondrial Function in HEK293 Cells

Open Access

Peer-reviewed

Research Article

Michelle Barbi de Moura,

Affiliations Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America
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Radha Uppala,

Affiliation Division of Medical Genetics, Department of Pediatrics, Children’s Hospital of Pittsburgh of The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
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Yuxun Zhang,

Affiliation Division of Medical Genetics, Department of Pediatrics, Children’s Hospital of Pittsburgh of The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
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Bennett Van Houten,

Affiliations Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America
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Eric S. Goetzman

* E-mail: eric.goetzman@chp.edu

Affiliation Division of Medical Genetics, Department of Pediatrics, Children’s Hospital of Pittsburgh of The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
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Mitochondria
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Oxygen consumption
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Glucose
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Oxidation
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Glycolysis
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Protons
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Fatty acids
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Superoxides
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