Melanocortin 1 Receptor-Signaling Deficiency Results in an Articular Cartilage Phenotype and Accelerates Pathogenesis of Surgically Induced Murine Osteoarthritis

• Julia Lorenz ,

  Contributed equally to this work with: Julia Lorenz, Elisabeth Seebach

  Affiliations Experimental Orthopedics, University Hospital of Regensburg, Regensburg, Bavaria, Germany, Orthopedic Surgery, University Hospital of Regensburg, Bad Abbach, Bavaria, Germany

  ⨯
• Elisabeth Seebach ,

  Contributed equally to this work with: Julia Lorenz, Elisabeth Seebach

  Affiliation Research Centre for Experimental Orthopedics, Orthopedic University Hospital Heidelberg, Heidelberg, Baden-Württemberg, Germany

  ⨯
• Gerit Hackmayer,

  Affiliations Experimental Orthopedics, University Hospital of Regensburg, Regensburg, Bavaria, Germany, Dermatology, University Hospital of Münster, Münster, North Rhine-Westphalia, Germany

  ⨯
• Carina Greth,

  Affiliation Research Centre for Experimental Orthopedics, Orthopedic University Hospital Heidelberg, Heidelberg, Baden-Württemberg, Germany

  ⨯
• Richard J. Bauer,

  Affiliation Oral and Maxillofacial Surgery, University Hospital of Regensburg, Regensburg, Bavaria, Germany

  ⨯
• Kerstin Kleinschmidt,

  Affiliation TIP Immunology, Merck Serono Global Research & Development, Darmstadt, Hessen, Germany

  ⨯
• Dominik Bettenworth,

  Affiliation Medical Hospital B, University Hospital of Münster, Münster, North Rhine-Westphalia, Germany

  ⨯
• Markus Böhm,

  Affiliation Dermatology, University Hospital of Münster, Münster, North Rhine-Westphalia, Germany

  ⨯
• Joachim Grifka,

  Affiliation Orthopedic Surgery, University Hospital of Regensburg, Bad Abbach, Bavaria, Germany

  ⨯
• Susanne Grässel

  * E-mail: susanne.graessel@klinik.uni-regensburg.de

  Affiliations Experimental Orthopedics, University Hospital of Regensburg, Regensburg, Bavaria, Germany, Orthopedic Surgery, University Hospital of Regensburg, Bad Abbach, Bavaria, Germany

  ⨯