Fibronectin Affects Transient MMP2 Gene Expression through DNA Demethylation Changes in Non-Invasive Breast Cancer Cell Lines

Isabela T. Pereira; Edneia A. S. Ramos; Erico T. Costa; Anamaria A. Camargo; Graciele C. M. Manica; Liliane M. B. Klassen; Andressa Chequin; Karin Braun-Prado; Fábio de O. Pedrosa; Emanuel M. Souza; Fabricio F. Costa; Giseli Klassen

doi:10.1371/journal.pone.0105806

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Open Access

Peer-reviewed

Research Article

Fibronectin Affects Transient MMP2 Gene Expression through DNA Demethylation Changes in Non-Invasive Breast Cancer Cell Lines

Isabela T. Pereira ,

Contributed equally to this work with: Isabela T. Pereira, Edneia A. S. Ramos

Affiliation Department of Basic Pathology, Federal University of Parana, Curitiba, Paraná, Brazil
⨯
Edneia A. S. Ramos ,

Contributed equally to this work with: Isabela T. Pereira, Edneia A. S. Ramos

Affiliation Department of Basic Pathology, Federal University of Parana, Curitiba, Paraná, Brazil
⨯
Erico T. Costa,

Affiliation Ludwig Institute for Cancer Research (LICR) at Molecular Oncology Center, Sirio-Libanes Hospital, São Paulo, São Paulo, Brazil
⨯
Anamaria A. Camargo,

Affiliation Ludwig Institute for Cancer Research (LICR) at Molecular Oncology Center, Sirio-Libanes Hospital, São Paulo, São Paulo, Brazil
⨯
Graciele C. M. Manica,

Affiliation Department of Basic Pathology, Federal University of Parana, Curitiba, Paraná, Brazil
⨯
Liliane M. B. Klassen,

Affiliation Department of Basic Pathology, Federal University of Parana, Curitiba, Paraná, Brazil
⨯
Andressa Chequin,

Affiliation Department of Basic Pathology, Federal University of Parana, Curitiba, Paraná, Brazil
⨯
Karin Braun-Prado,

Affiliation Department of Basic Pathology, Federal University of Parana, Curitiba, Paraná, Brazil
⨯
Fábio de O. Pedrosa,

Affiliation Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Parana, Brazil
⨯
Emanuel M. Souza,

Affiliation Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Parana, Brazil
⨯
Fabricio F. Costa,

Affiliation Cancer Biology and Epigenomics Program, Ann and Robert Lurie Children’s Hospital of Chicago Research Center and Department of Pediatrics, Northwestern University’s Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Giseli Klassen

* E-mail: giseli@ufpr.br

Affiliation Department of Basic Pathology, Federal University of Parana, Curitiba, Paraná, Brazil
⨯

Fibronectin Affects Transient MMP2 Gene Expression through DNA Demethylation Changes in Non-Invasive Breast Cancer Cell Lines

Isabela T. Pereira,
Edneia A. S. Ramos,
Erico T. Costa,
Anamaria A. Camargo,
Graciele C. M. Manica,
Liliane M. B. Klassen,
Andressa Chequin,
Karin Braun-Prado,
Fábio de O. Pedrosa,
Emanuel M. Souza

Published: September 10, 2014
https://doi.org/10.1371/journal.pone.0105806

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