Oral Administration of Recombinant Lactococcus lactis Expressing HSP65 and Tandemly Repeated P277 Reduces the Incidence of Type I Diabetes in Non-Obese Diabetic Mice

Yanjun Ma; Jingjing Liu; Jing Hou; Yuankai Dong; Yong Lu; Liang Jin; Rongyue Cao; Taiming Li; Jie Wu

doi:10.1371/journal.pone.0105701

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Peer-reviewed

Research Article

Oral Administration of Recombinant Lactococcus lactis Expressing HSP65 and Tandemly Repeated P277 Reduces the Incidence of Type I Diabetes in Non-Obese Diabetic Mice

Yanjun Ma,

Affiliations Forensic Center, Nanjing Forest Police College, Nanjing, People's Republic of China, Minigene Pharmacy Laboratory, School of life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China
⨯
Jingjing Liu,

Affiliation Minigene Pharmacy Laboratory, School of life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China
⨯
Jing Hou,

Affiliation Minigene Pharmacy Laboratory, School of life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China
⨯
Yuankai Dong,

Affiliation Minigene Pharmacy Laboratory, School of life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China
⨯
Yong Lu,

Affiliation Minigene Pharmacy Laboratory, School of life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China
⨯
Liang Jin,

Affiliation Minigene Pharmacy Laboratory, School of life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China
⨯
Rongyue Cao,

Affiliation Minigene Pharmacy Laboratory, School of life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China
⨯
Taiming Li,

Affiliation Minigene Pharmacy Laboratory, School of life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China
⨯
Jie Wu

* E-mail: wujie@cpu.edu.cn

Affiliation Minigene Pharmacy Laboratory, School of life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China
⨯

Oral Administration of Recombinant Lactococcus lactis Expressing HSP65 and Tandemly Repeated P277 Reduces the Incidence of Type I Diabetes in Non-Obese Diabetic Mice

Yanjun Ma,
Jingjing Liu,
Jing Hou,
Yuankai Dong,
Yong Lu,
Liang Jin,
Rongyue Cao,
Taiming Li,
Jie Wu

Published: August 26, 2014
https://doi.org/10.1371/journal.pone.0105701

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Lactococcus lactis
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Insulitis
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Oral administration
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