miR-203 Suppresses the Proliferation and Migration and Promotes the Apoptosis of Lung Cancer Cells by Targeting SRC

Nan Wang; Hongwei Liang; Yong Zhou; Chen Wang; Suyang Zhang; Yi Pan; Yanbo Wang; Xin Yan; Junfeng Zhang; Chen-Yu Zhang; Ke Zen; Donghai Li; Xi Chen

doi:10.1371/journal.pone.0105570

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Open Access

Peer-reviewed

Research Article

miR-203 Suppresses the Proliferation and Migration and Promotes the Apoptosis of Lung Cancer Cells by Targeting SRC

Nan Wang ,

Contributed equally to this work with: Nan Wang, Hongwei Liang, Yong Zhou, Chen Wang

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Hongwei Liang ,

Contributed equally to this work with: Nan Wang, Hongwei Liang, Yong Zhou, Chen Wang

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Yong Zhou ,

Contributed equally to this work with: Nan Wang, Hongwei Liang, Yong Zhou, Chen Wang

Affiliation Department of Thoracic and Cardiovascular surgery, Affiliated Gulou Hospital, Medical college of Nanjing University, Nanjing, Jiangsu, China
⨯
Chen Wang ,

Contributed equally to this work with: Nan Wang, Hongwei Liang, Yong Zhou, Chen Wang

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Suyang Zhang,

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Yi Pan,

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Yanbo Wang,

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Xin Yan,

Affiliation The Comprehensive Cancer Center of Drum Tower Hospital affiliated to Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu, China
⨯
Junfeng Zhang,

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Chen-Yu Zhang,

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Ke Zen,

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Donghai Li ,

* E-mail: xichen@nju.edu.cn (XC); or donghaili@nju.edu.cn (DL)

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Xi Chen

* E-mail: xichen@nju.edu.cn (XC); or donghaili@nju.edu.cn (DL)

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯

miR-203 Suppresses the Proliferation and Migration and Promotes the Apoptosis of Lung Cancer Cells by Targeting SRC

Nan Wang,
Hongwei Liang,
Yong Zhou,
Chen Wang,
Suyang Zhang,
Yi Pan,
Yanbo Wang,
Xin Yan,
Junfeng Zhang,
Chen-Yu Zhang

Published: August 20, 2014
https://doi.org/10.1371/journal.pone.0105570

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Lung and intrathoracic tumors
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Transfection
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Apoptosis
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MicroRNAs
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Gene expression
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Small interfering RNA
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Non-small cell lung cancer
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