Mst1 Directs Myosin IIa Partitioning of Low and Higher Affinity Integrins during T Cell Migration

Xiaolu Xu; Emily R. Jaeger; Xinxin Wang; Erica Lagler-Ferrez; Serge Batalov; Nancy L. Mathis; Tim Wiltshire; John R. Walker; Michael P. Cooke; Karsten Sauer; Yina H. Huang

doi:10.1371/journal.pone.0105561

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Open Access

Peer-reviewed

Research Article

Mst1 Directs Myosin IIa Partitioning of Low and Higher Affinity Integrins during T Cell Migration

Xiaolu Xu,

Affiliation Department of Pathology and Immunology, Washington University, St. Louis, Missouri, United States of America
⨯
Emily R. Jaeger,

Affiliation Department of Pathology and Immunology, Washington University, St. Louis, Missouri, United States of America
⨯
Xinxin Wang,

Affiliation Department of Pathology and Immunology, Washington University, St. Louis, Missouri, United States of America
⨯
Erica Lagler-Ferrez,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Serge Batalov,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Nancy L. Mathis,

Affiliation Department of Pathology and Immunology, Washington University, St. Louis, Missouri, United States of America
⨯
Tim Wiltshire,

Affiliation Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
John R. Walker,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Michael P. Cooke,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Karsten Sauer ,

* E-mail: ksauer@scripps.edu (KS); yina.h.huang@dartmouth.edu (YHH)

Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Yina H. Huang

* E-mail: ksauer@scripps.edu (KS); yina.h.huang@dartmouth.edu (YHH)

Affiliations Department of Pathology and Immunology, Washington University, St. Louis, Missouri, United States of America, Departments of Pathology and Microbiology & Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America
⨯

Mst1 Directs Myosin IIa Partitioning of Low and Higher Affinity Integrins during T Cell Migration

Xiaolu Xu,
Emily R. Jaeger,
Xinxin Wang,
Erica Lagler-Ferrez,
Serge Batalov,
Nancy L. Mathis,
Tim Wiltshire,
John R. Walker,
Michael P. Cooke,
Karsten Sauer

Published: August 18, 2014
https://doi.org/10.1371/journal.pone.0105561

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T cells
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Myosins
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T helper cells
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Integrins
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T cell receptors
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Cell migration
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