Structure Driven Design of Novel Human Ether-A-Go-Go-Related-Gene Channel (hERG1) Activators

Jiqing Guo; Serdar Durdagi; Mohamed Changalov; Laura L. Perissinotti; Jason M. Hargreaves; Thomas G. Back; Sergei Y. Noskov; Henry J. Duff

doi:10.1371/journal.pone.0105553

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Open Access

Peer-reviewed

Research Article

Structure Driven Design of Novel Human Ether-A-Go-Go-Related-Gene Channel (hERG1) Activators

Jiqing Guo ,

Contributed equally to this work with: Jiqing Guo, Serdar Durdagi, Mohamed Changalov

Affiliation Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
⨯
Serdar Durdagi ,

Contributed equally to this work with: Jiqing Guo, Serdar Durdagi, Mohamed Changalov

Affiliations Centre for Molecular Simulation, Biochemistry Research Cluster, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada, Department of Biophysics, School of Medicine, Bahcesehir University, Istanbul, Turkey
⨯
Mohamed Changalov ,

Contributed equally to this work with: Jiqing Guo, Serdar Durdagi, Mohamed Changalov

Affiliation Department of Chemistry, University of Calgary, Calgary, Alberta, Canada
⨯
Laura L. Perissinotti,

Affiliation Centre for Molecular Simulation, Biochemistry Research Cluster, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
⨯
Jason M. Hargreaves,

Affiliation Department of Chemistry, University of Calgary, Calgary, Alberta, Canada
⨯
Thomas G. Back ,

* E-mail: tgback@ucalgary.ca (TGB); snoskov@ucalgary.ca (SYN); hduff@ucalgary.ca (HJD)

Affiliation Department of Chemistry, University of Calgary, Calgary, Alberta, Canada
⨯
Sergei Y. Noskov ,

* E-mail: tgback@ucalgary.ca (TGB); snoskov@ucalgary.ca (SYN); hduff@ucalgary.ca (HJD)

Affiliation Centre for Molecular Simulation, Biochemistry Research Cluster, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
⨯
Henry J. Duff

* E-mail: tgback@ucalgary.ca (TGB); snoskov@ucalgary.ca (SYN); hduff@ucalgary.ca (HJD)

Affiliation Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
⨯

Structure Driven Design of Novel Human Ether-A-Go-Go-Related-Gene Channel (hERG1) Activators

Jiqing Guo,
Serdar Durdagi,
Mohamed Changalov,
Laura L. Perissinotti,
Jason M. Hargreaves,
Thomas G. Back,
Sergei Y. Noskov,
Henry J. Duff

Published: September 5, 2014
https://doi.org/10.1371/journal.pone.0105553

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