SH3BP2 Gain-Of-Function Mutation Exacerbates Inflammation and Bone Loss in a Murine Collagen-Induced Arthritis Model

Tomoyuki Mukai; Richard Gallant; Shu Ishida; Teruhito Yoshitaka; Mizuho Kittaka; Keiichiro Nishida; David A. Fox; Yoshitaka Morita; Yasuyoshi Ueki

doi:10.1371/journal.pone.0105518

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Peer-reviewed

Research Article

SH3BP2 Gain-Of-Function Mutation Exacerbates Inflammation and Bone Loss in a Murine Collagen-Induced Arthritis Model

Tomoyuki Mukai,

Affiliation Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, United States of America
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Richard Gallant,

Affiliation Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, United States of America
⨯
Shu Ishida,

Affiliations Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, United States of America, Department of Periodontal Medicine, Applied life Sciences, Institute of Biomedical and Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
⨯
Teruhito Yoshitaka,

Affiliation Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, United States of America
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Mizuho Kittaka,

Affiliation Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, United States of America
⨯
Keiichiro Nishida,

Affiliations Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
David A. Fox,

Affiliation Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
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Yoshitaka Morita,

Affiliation Department of Rheumatology, Kawasaki Medical School, Kurashiki, Japan
⨯
Yasuyoshi Ueki

* E-mail: uekiy@umkc.edu

Affiliation Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, United States of America
⨯

SH3BP2 Gain-Of-Function Mutation Exacerbates Inflammation and Bone Loss in a Murine Collagen-Induced Arthritis Model

Tomoyuki Mukai,
Richard Gallant,
Shu Ishida,
Teruhito Yoshitaka,
Mizuho Kittaka,
Keiichiro Nishida,
David A. Fox,
Yoshitaka Morita,
Yasuyoshi Ueki

Published: August 21, 2014
https://doi.org/10.1371/journal.pone.0105518

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Osteoclasts
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Skeletal joints
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