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Open Access
Peer-reviewed
Research Article
Increased Presence of FOXP3+ Regulatory T Cells in Inflamed Muscle of Patients with Active Juvenile Dermatomyositis Compared to Peripheral Blood
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Yvonne Vercoulen ,
* E-mail: y.vercoulen@umcutrecht.nl (YV); A.vanRoyen@umcutrecht.nl (AR)
Current address: University of California San Francisco, San Francisco, CA, United States of America
Affiliation Laboratory of Translational Immunology, Pediatric Immunology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Felicitas Bellutti Enders,
Affiliations Laboratory of Translational Immunology, Pediatric Immunology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands, Division of Allergology, Immunology and Rheumatology, Department of Pediatrics, University Hospital, Lausanne, Switzerland
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Jenny Meerding,
Affiliation Laboratory of Translational Immunology, Pediatric Immunology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Maud Plantinga,
Affiliation Laboratory of Translational Immunology, Pediatric Immunology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Elisabeth F. Elst,
Affiliation Laboratory of Translational Immunology, Pediatric Immunology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Hemlata Varsani,
Affiliation Rheumatology Unit, University College London Institute of Child Health, on behalf of the Juvenile Dermatomyositis Research Group (UK and Ireland), London, United Kingdom
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Christa van Schieveen,
Affiliation Laboratory of Translational Immunology, Pediatric Immunology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Mette H. Bakker,
Affiliation Laboratory of Translational Immunology, Pediatric Immunology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Mark Klein,
Affiliation Laboratory of Translational Immunology, Pediatric Immunology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Rianne C. Scholman,
Affiliation Laboratory of Translational Immunology, Pediatric Immunology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Wim Spliet,
Affiliation Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
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Valeria Ricotti,
Affiliation Dubowitz Neuromuscular Centre, University College London Institute of Child Health, London, United Kingdom
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Hans J. P. M. Koenen,
Affiliation Department Laboratory Medicine, Section Medical Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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Roel A. de Weger,
Affiliation Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
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Lucy R. Wedderburn,
Affiliation Rheumatology Unit, University College London Institute of Child Health, on behalf of the Juvenile Dermatomyositis Research Group (UK and Ireland), London, United Kingdom
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Annet van Royen-Kerkhof ,
Contributed equally to this work with: Annet van Royen-Kerkhof, Berent J. Prakken
* E-mail: y.vercoulen@umcutrecht.nl (YV); A.vanRoyen@umcutrecht.nl (AR)
Affiliation Department of Pediatric Immunology and Rheumatology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Berent J. Prakken
Contributed equally to this work with: Annet van Royen-Kerkhof, Berent J. Prakken
Affiliation Laboratory of Translational Immunology, Pediatric Immunology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Increased Presence of FOXP3+ Regulatory T Cells in Inflamed Muscle of Patients with Active Juvenile Dermatomyositis Compared to Peripheral Blood
- Yvonne Vercoulen,
- Felicitas Bellutti Enders,
- Jenny Meerding,
- Maud Plantinga,
- Elisabeth F. Elst,
- Hemlata Varsani,
- Christa van Schieveen,
- Mette H. Bakker,
- Mark Klein,
- Rianne C. Scholman
- Published: August 26, 2014
- https://doi.org/10.1371/journal.pone.0105353