Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis

Suresh B. Lakshminarayana; Helena I. M. Boshoff; Joseph Cherian; Sindhu Ravindran; Anne Goh; Jan Jiricek; Mahesh Nanjundappa; Amit Nayyar; Meera Gurumurthy; Ramandeep Singh; Thomas Dick; Francesca Blasco; Clifton E. Barry III; Paul C. Ho; Ujjini H. Manjunatha

doi:10.1371/journal.pone.0105222

Loading metrics

Open Access

Peer-reviewed

Research Article

Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis

Suresh B. Lakshminarayana ,

* E-mail: suresh.b_lakshminarayana@novartis.com (SBL); manjunatha.ujjini@novartis.com (UHM)

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Helena I. M. Boshoff,

Affiliation Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Joseph Cherian,

Current address: Experimental Therapeutics Centre, Singapore, Singapore

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Sindhu Ravindran,

Current address: National University Health System, Singapore, Singapore

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Anne Goh,

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Jan Jiricek,

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Mahesh Nanjundappa,

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Amit Nayyar,

Current address: AMRI Singapore Research Center, Singapore, Singapore

Affiliation Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Meera Gurumurthy,

Current address: Department of Microbiology, Yong Loo Lin School of Medicine, National University Health system, National University of Singapore, Singapore

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Ramandeep Singh,

Current address: Translational Health Science and Technology Institute, Gurgaon, Haryana, India

Affiliation Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Thomas Dick,

Current address: Department of Microbiology, Yong Loo Lin School of Medicine, National University Health system, National University of Singapore, Singapore

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Francesca Blasco,

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯
Clifton E. Barry III,

Affiliation Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Paul C. Ho,

Affiliation Department of Pharmacy, National University of Singapore, Singapore, Singapore
⨯
Ujjini H. Manjunatha

* E-mail: suresh.b_lakshminarayana@novartis.com (SBL); manjunatha.ujjini@novartis.com (UHM)

Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore
⨯

Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis

Suresh B. Lakshminarayana,
Helena I. M. Boshoff,
Joseph Cherian,
Sindhu Ravindran,
Anne Goh,
Jan Jiricek,
Mahesh Nanjundappa,
Amit Nayyar,
Meera Gurumurthy,
Ramandeep Singh

Published: August 20, 2014
https://doi.org/10.1371/journal.pone.0105222

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Tuberculosis drug discovery
Is the Subject Area "Tuberculosis drug discovery" applicable to this article?

Thanks for your feedback.
Mycobacterium tuberculosis
Is the Subject Area "Mycobacterium tuberculosis" applicable to this article?

Thanks for your feedback.
Blood plasma
Is the Subject Area "Blood plasma" applicable to this article?

Thanks for your feedback.
Solubility
Is the Subject Area "Solubility" applicable to this article?

Thanks for your feedback.
Tuberculosis
Is the Subject Area "Tuberculosis" applicable to this article?

Thanks for your feedback.
Plasma proteins
Is the Subject Area "Plasma proteins" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Drug discovery
Is the Subject Area "Drug discovery" applicable to this article?

Thanks for your feedback.