Application of a Combination of a Knowledge-Based Algorithm and 2-Stage Screening to Hypothesis-Free Genomic Data on Irinotecan-Treated Patients for Identification of a Candidate Single Nucleotide Polymorphism Related to an Adverse Effect

• Hiro Takahashi ,

  * E-mail: hiro.takahashi@chiba-u.jp

  Affiliations Graduate School of Horticulture, Chiba University, Matsudo, Chiba, Japan, Plant Biology Research Center, Chubu University, Kasugai, Aichi, Japan, Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan

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• Kimie Sai,

  Affiliation Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan

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• Yoshiro Saito,

  Affiliation Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan

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• Nahoko Kaniwa,

  Affiliation Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan

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• Yasuhiro Matsumura,

  Affiliation Division of Developmental Therapeutics, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan

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• Tetsuya Hamaguchi,

  Affiliation Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan

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• Yasuhiro Shimada,

  Affiliation Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan

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• Atsushi Ohtsu,

  Affiliation Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan

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• Takayuki Yoshino,

  Affiliation Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan

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• Toshihiko Doi,

  Affiliation Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan

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• Haruhiro Okuda,

  Affiliation Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan

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• Risa Ichinohe,

  Affiliations Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan, Faculty of Horticulture, Chiba University, Matsudo, Chiba, Japan

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• Anna Takahashi,

  Affiliation Plant Biology Research Center, Chubu University, Kasugai, Aichi, Japan

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• Ayano Doi,

  Affiliations Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan, Faculty of Horticulture, Chiba University, Matsudo, Chiba, Japan

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• Yoko Odaka,

  Affiliation Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan

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• Misuzu Okuyama,

  Affiliation Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan

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• Nagahiro Saijo,

  Current address: Japanese Society of Medical Oncology, Tokyo, Japan

  Affiliation National Cancer Center Hospital East, Kashiwa, Chiba, Japan

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• Jun-ichi Sawada,

  Current address: Pharmaceutical and Medical Devices Agency, Tokyo, Japan

  Affiliation Division of Functional Biochemistry and Genomics, National Institute of Health Sciences, Tokyo, Japan

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• Hiromi Sakamoto,

  Affiliation Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan

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•  [ ... ],
• Teruhiko Yoshida

  Affiliation Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan

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