The DNA Binding Property of PML/RARA but Not the Integrity of PML Nuclear Bodies Is Indispensable for Leukemic Transformation

Xi Liu; Hao Yuan; Laurent Peres; Saijuan Chen; Zhu Chen; Hugues de The; Jun Zhou; Jun Zhu

doi:10.1371/journal.pone.0104906

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Peer-reviewed

Research Article

The DNA Binding Property of PML/RARA but Not the Integrity of PML Nuclear Bodies Is Indispensable for Leukemic Transformation

Xi Liu,

Affiliation CNRS-LIA124, Sino-French Research Center for Life Sciences and Genomics, State Key Laboratory of Medical Genomics, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Hao Yuan,

Affiliation CNRS-LIA124, Sino-French Research Center for Life Sciences and Genomics, State Key Laboratory of Medical Genomics, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Laurent Peres,

Affiliation Université de Paris 7/INSERM/CNRS UMR 944/7151, Equipe Labellisée No. 11 Ligue Nationale Contre le Cancer, Hôpital St. Louis, Paris, France
⨯
Saijuan Chen,

Affiliation CNRS-LIA124, Sino-French Research Center for Life Sciences and Genomics, State Key Laboratory of Medical Genomics, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Zhu Chen,

Affiliation CNRS-LIA124, Sino-French Research Center for Life Sciences and Genomics, State Key Laboratory of Medical Genomics, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Hugues de The,

Affiliations CNRS-LIA124, Sino-French Research Center for Life Sciences and Genomics, State Key Laboratory of Medical Genomics, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Université de Paris 7/INSERM/CNRS UMR 944/7151, Equipe Labellisée No. 11 Ligue Nationale Contre le Cancer, Hôpital St. Louis, Paris, France
⨯
Jun Zhou ,

* E-mail: junjun_j@yahoo.com (J. Zhou); zhuj1966@yahoo.com ((J. Zhu)

Affiliation CNRS-LIA124, Sino-French Research Center for Life Sciences and Genomics, State Key Laboratory of Medical Genomics, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Jun Zhu

* E-mail: junjun_j@yahoo.com (J. Zhou); zhuj1966@yahoo.com ((J. Zhu)

Affiliations CNRS-LIA124, Sino-French Research Center for Life Sciences and Genomics, State Key Laboratory of Medical Genomics, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Université de Paris 7/INSERM/CNRS UMR 944/7151, Equipe Labellisée No. 11 Ligue Nationale Contre le Cancer, Hôpital St. Louis, Paris, France
⨯

The DNA Binding Property of PML/RARA but Not the Integrity of PML Nuclear Bodies Is Indispensable for Leukemic Transformation

Xi Liu,
Hao Yuan,
Laurent Peres,
Saijuan Chen,
Zhu Chen,
Hugues de The,
Jun Zhou,
Jun Zhu

Published: August 13, 2014
https://doi.org/10.1371/journal.pone.0104906

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DNA-binding proteins
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Nuclear bodies
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DNA binding assay
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Cell binding
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Transfection
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Cell differentiation
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Cell disruption
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Gene expression
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