Divergent Effects of Liraglutide, Exendin-4, and Sitagliptin on Beta-Cell Mass and Indicators of Pancreatitis in a Mouse Model of Hyperglycaemia

Angeles Mondragon; Daniel Davidsson; Styliana Kyriakoudi; Annika Bertling; Rosa Gomes-Faria; Patrizia Cohen; Stephen Rothery; Pauline Chabosseau; Guy A. Rutter; Gabriela da Silva Xavier

doi:10.1371/journal.pone.0104873

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Peer-reviewed

Research Article

Divergent Effects of Liraglutide, Exendin-4, and Sitagliptin on Beta-Cell Mass and Indicators of Pancreatitis in a Mouse Model of Hyperglycaemia

Angeles Mondragon,

Affiliation Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Daniel Davidsson,

Affiliation Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Styliana Kyriakoudi,

Affiliation Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Annika Bertling,

Affiliation Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Rosa Gomes-Faria,

Affiliation Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Patrizia Cohen,

Affiliation Imperial College Healthcare NHS Trust, Department of Pathology, St. Mary's Hospital, London, United Kingdom
⨯
Stephen Rothery,

Affiliation FILM, Imperial College London, London, United Kingdom
⨯
Pauline Chabosseau,

Affiliation Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Guy A. Rutter,

Affiliation Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Gabriela da Silva Xavier

* E-mail: g.dasilva-xavier@imperial.ac.uk

Affiliation Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯

Divergent Effects of Liraglutide, Exendin-4, and Sitagliptin on Beta-Cell Mass and Indicators of Pancreatitis in a Mouse Model of Hyperglycaemia

Angeles Mondragon,
Daniel Davidsson,
Styliana Kyriakoudi,
Annika Bertling,
Rosa Gomes-Faria,
Patrizia Cohen,
Stephen Rothery,
Pauline Chabosseau,
Guy A. Rutter,
Gabriela da Silva Xavier

Published: August 13, 2014
https://doi.org/10.1371/journal.pone.0104873

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