Intranasal Delivery of Influenza rNP Adjuvanted with c-di-AMP Induces Strong Humoral and Cellular Immune Responses and Provides Protection against Virus Challenge

• Maria Victoria Sanchez,

  Affiliations Laboratory of Virology, Institute of Experimental Medicine and Biology of Cuyo (IMBECU-CCT, CONICET), Mendoza, Argentina, Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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• Thomas Ebensen ,

  * E-mail: Thomas.Ebensen@helmholtz-hzi.de

  Affiliation Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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• Kai Schulze,

  Affiliation Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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• Diego Cargnelutti,

  Affiliation Laboratory of Virology, Institute of Experimental Medicine and Biology of Cuyo (IMBECU-CCT, CONICET), Mendoza, Argentina

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• Paulina Blazejewska,

  Affiliation Boehringer Ingelheim Veterinary Research Center GmbH & Co. KG, Hannover, Germany

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• Eduardo A. Scodeller,

  Affiliation Laboratory of Virology, Institute of Experimental Medicine and Biology of Cuyo (IMBECU-CCT, CONICET), Mendoza, Argentina

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• Carlos A. Guzmán

  Affiliation Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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