The p53-Reactivating Small Molecule RITA Induces Senescence in Head and Neck Cancer Cells

Hui-Ching Chuang; Liang Peng Yang; Alison L. Fitzgerald; Abdullah Osman; Sang Hyeok Woo; Jeffrey N. Myers; Heath D. Skinner

doi:10.1371/journal.pone.0104821

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Peer-reviewed

Research Article

The p53-Reactivating Small Molecule RITA Induces Senescence in Head and Neck Cancer Cells

Hui-Ching Chuang,

Affiliations Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
⨯
Liang Peng Yang,

Affiliation Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Alison L. Fitzgerald,

Affiliations Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Abdullah Osman,

Affiliation Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Sang Hyeok Woo,

Affiliation Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Jeffrey N. Myers,

Affiliations Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Heath D. Skinner

* E-mail: hskinner@mdanderson.org

Affiliation Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯

The p53-Reactivating Small Molecule RITA Induces Senescence in Head and Neck Cancer Cells

Hui-Ching Chuang,
Liang Peng Yang,
Alison L. Fitzgerald,
Abdullah Osman,
Sang Hyeok Woo,
Jeffrey N. Myers,
Heath D. Skinner

Published: August 13, 2014
https://doi.org/10.1371/journal.pone.0104821

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Cell staining
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Head and neck squamous cell carcinoma
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Head and neck cancers
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