Polycomb Group Protein Ezh2 Regulates Hepatic Progenitor Cell Proliferation and Differentiation in Murine Embryonic Liver

Hiroyuki Koike; Rie Ouchi; Yasuharu Ueno; Susumu Nakata; Yuta Obana; Keisuke Sekine; Yun-Wen Zheng; Takanori Takebe; Kyoichi Isono; Haruhiko Koseki; Hideki Taniguchi

doi:10.1371/journal.pone.0104776

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Open Access

Peer-reviewed

Research Article

Polycomb Group Protein Ezh2 Regulates Hepatic Progenitor Cell Proliferation and Differentiation in Murine Embryonic Liver

Hiroyuki Koike ,

Contributed equally to this work with: Hiroyuki Koike, Rie Ouchi

Affiliation Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Kanagawa, Japan
⨯
Rie Ouchi ,

Contributed equally to this work with: Hiroyuki Koike, Rie Ouchi

Affiliation Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Kanagawa, Japan
⨯
Yasuharu Ueno,

Affiliation Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Kanagawa, Japan
⨯
Susumu Nakata,

Affiliation Division of Oncological Pathology, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan
⨯
Yuta Obana,

Affiliation Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Kanagawa, Japan
⨯
Keisuke Sekine,

Affiliation Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Kanagawa, Japan
⨯
Yun-Wen Zheng,

Affiliation Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Kanagawa, Japan
⨯
Takanori Takebe,

Affiliations Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Kanagawa, Japan, Project Leader of Advanced Medical Research Center, Yokohama City University, Kanazawa-ku, Yokohama, Kanagawa, Japan, PRESTO, Japan Science and Technology Agency, Saitama, Japan
⨯
Kyoichi Isono,

Affiliation Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Kanagawa, Japan
⨯
Haruhiko Koseki,

Affiliation Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Kanagawa, Japan
⨯
Hideki Taniguchi

* E-mail: rtanigu@med.yokohama-cu.ac.jp

Affiliations Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Kanagawa, Japan, Project Leader of Advanced Medical Research Center, Yokohama City University, Kanazawa-ku, Yokohama, Kanagawa, Japan
⨯

Polycomb Group Protein Ezh2 Regulates Hepatic Progenitor Cell Proliferation and Differentiation in Murine Embryonic Liver

Hiroyuki Koike,
Rie Ouchi,
Yasuharu Ueno,
Susumu Nakata,
Yuta Obana,
Keisuke Sekine,
Yun-Wen Zheng,
Takanori Takebe,
Kyoichi Isono,
Haruhiko Koseki

Published: August 25, 2014
https://doi.org/10.1371/journal.pone.0104776

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