Binding of HIV-1 gp41-Directed Neutralizing and Non-Neutralizing Fragment Antibody Binding Domain (Fab) and Single Chain Variable Fragment (ScFv) Antibodies to the Ectodomain of gp41 in the Pre-Hairpin and Six-Helix Bundle Conformations

John M. Louis; Annie Aniana; Katheryn Lohith; Jane M. Sayer; Julien Roche; Carole A. Bewley; G. Marius Clore

doi:10.1371/journal.pone.0104683

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Research Article

Binding of HIV-1 gp41-Directed Neutralizing and Non-Neutralizing Fragment Antibody Binding Domain (Fab) and Single Chain Variable Fragment (ScFv) Antibodies to the Ectodomain of gp41 in the Pre-Hairpin and Six-Helix Bundle Conformations

John M. Louis ,

* E-mail: johnl@niddk.nih.gov (JML); mariusc@mail.nih.gov (GMC)

Affiliation Laboratories of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Annie Aniana,

Affiliation Laboratories of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Katheryn Lohith,

Affiliation Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Jane M. Sayer,

Affiliation Laboratories of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Julien Roche,

Affiliation Laboratories of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Carole A. Bewley,

Affiliation Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
G. Marius Clore

* E-mail: johnl@niddk.nih.gov (JML); mariusc@mail.nih.gov (GMC)

Affiliation Laboratories of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Binding of HIV-1 gp41-Directed Neutralizing and Non-Neutralizing Fragment Antibody Binding Domain (Fab) and Single Chain Variable Fragment (ScFv) Antibodies to the Ectodomain of gp41 in the Pre-Hairpin and Six-Helix Bundle Conformations

John M. Louis,
Annie Aniana,
Katheryn Lohith,
Jane M. Sayer,
Julien Roche,
Carole A. Bewley,
G. Marius Clore

Published: August 8, 2014
https://doi.org/10.1371/journal.pone.0104683

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