Nerve Growth Factor Mediates a Switch in Intracellular Signaling for PGE2-Induced Sensitization of Sensory Neurons from Protein Kinase A to Epac

Open Access

Peer-reviewed

Research Article

Nerve Growth Factor Mediates a Switch in Intracellular Signaling for PGE₂-Induced Sensitization of Sensory Neurons from Protein Kinase A to Epac

Michael R. Vasko ,

* E-mail: vaskom@iupui.edu

Affiliations Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Anesthesia, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Ramy Habashy Malty,

Affiliations Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
⨯
Chunlu Guo,

Affiliation Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Djane B. Duarte,

Affiliation Faculdade De Ciências da Saúde-FS, Universidade De Brasília-UNB Campus Universitário Darcy, Ribeiro-Asa Norte, Brazil
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Yihong Zhang,

Affiliation Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Grant D. Nicol

Affiliation Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Sensory neurons
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Sensory perception
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Inflammation
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Small interfering RNA
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Neurons
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PKA signaling cascade
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Sensory receptors
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Spinal cord
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