The Flavones Apigenin and Luteolin Induce FOXO1 Translocation but Inhibit Gluconeogenic and Lipogenic Gene Expression in Human Cells

Christiane Bumke-Vogt; Martin A. Osterhoff; Andrea Borchert; Valentina Guzman-Perez; Zeinab Sarem; Andreas L. Birkenfeld; Volker Bähr; Andreas F. H. Pfeiffer

doi:10.1371/journal.pone.0104321

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Peer-reviewed

Research Article

The Flavones Apigenin and Luteolin Induce FOXO1 Translocation but Inhibit Gluconeogenic and Lipogenic Gene Expression in Human Cells

Christiane Bumke-Vogt,

Affiliations Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany, Department of Endocrinology, Diabetes and Nutrition, Charité - University Medicine Berlin, Berlin, Germany
⨯
Martin A. Osterhoff ,

* E-mail: martino@dife.de

Affiliations Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany, Department of Endocrinology, Diabetes and Nutrition, Charité - University Medicine Berlin, Berlin, Germany
⨯
Andrea Borchert,

Affiliation Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
⨯
Valentina Guzman-Perez,

Affiliations Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany, Department of Nutrition and Biochemistry, Sciences Faculty - Pontificia Universidad Javeriana, Bogota D.C., Colombia
⨯
Zeinab Sarem,

Affiliation Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany
⨯
Andreas L. Birkenfeld,

Affiliation Department of Endocrinology, Diabetes and Nutrition, Charité - University Medicine Berlin, Berlin, Germany
⨯
Volker Bähr,

Affiliation Department of Endocrinology, Diabetes and Nutrition, Charité - University Medicine Berlin, Berlin, Germany
⨯
Andreas F. H. Pfeiffer

Affiliations Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany, Department of Endocrinology, Diabetes and Nutrition, Charité - University Medicine Berlin, Berlin, Germany
⨯

The Flavones Apigenin and Luteolin Induce FOXO1 Translocation but Inhibit Gluconeogenic and Lipogenic Gene Expression in Human Cells

Christiane Bumke-Vogt,
Martin A. Osterhoff,
Andrea Borchert,
Valentina Guzman-Perez,
Zeinab Sarem,
Andreas L. Birkenfeld,
Volker Bähr,
Andreas F. H. Pfeiffer

Published: August 19, 2014
https://doi.org/10.1371/journal.pone.0104321

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