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Open Access

Peer-reviewed

Research Article

A New 2α,5α,10β,14β-tetraacetoxy-4(20),11-taxadiene (SIA) Derivative Overcomes Paclitaxel Resistance by Inhibiting MAPK Signaling and Increasing Paclitaxel Accumulation in Breast Cancer Cells

Mei Mei,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing City, China
⨯
Dan Xie,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing City, China
⨯
Yi Zhang,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing City, China
⨯
Jing Jin,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing City, China
⨯
Feng You,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing City, China
⨯
Yan Li,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing City, China
⨯
Jungui Dai,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing City, China
⨯
Xiaoguang Chen

* E-mail: chxg@imm.ac.cn

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing City, China
⨯

A New 2α,5α,10β,14β-tetraacetoxy-4(20),11-taxadiene (SIA) Derivative Overcomes Paclitaxel Resistance by Inhibiting MAPK Signaling and Increasing Paclitaxel Accumulation in Breast Cancer Cells

Mei Mei,
Dan Xie,
Yi Zhang,
Jing Jin,
Feng You,
Yan Li,
Jungui Dai,
Xiaoguang Chen

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Published: August 5, 2014
https://doi.org/10.1371/journal.pone.0104317

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Breast cancer
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Cancer treatment
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MAPK signaling cascades
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Apoptosis
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MTT assay
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Mouse models
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Non-small cell lung cancer
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Genetically modified animals
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